Missouri vs Louisiana Picks and Prediction for Saturday, September 13, 2025

By: Garrett Beaverson Published 09/08/2025, 02:35 AM ET

Missouri vs Louisiana Game Information

Missouri (2–0, ranked No. 25) hosts the Louisiana Ragin’ Cajuns (1–1) on Saturday, September 13, 2025, at 4:00 PM EST at Faurot Field in Columbia. The game will air on SEC Network+. Missouri enters the matchup buoyed by a dramatic 42–31 Border War win over Kansas, while Louisiana is coming off a convincing 34–10 victory over McNeese State. Missouri is a heavy favorite, with opening lines hovering between –21 to –25 points. Get in on the action with our free college football picks.

Louisiana Analysis

Louisiana (1–1) rebounded from an opening setback with a statement 34–10 victory over McNeese State. Freshman QB Daniel Beale took over after Walker Howard suffered an oblique injury and pushed the offense forward, though it remains a catalyst-driven group. The offense ranks 63rd nationally in third-down conversion (42.3%) and boasts productive running backs like Bill Davis (132 yards, 2 TDs) and Zylan Perry (94 yards) leading the charge.

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Missouri Analysis

Missouri (2–0) is off to a strong start under coach Eli Drinkwitz, rallying from multiple deficits to beat Kansas 42–31 and extending their non-conference home win streak. The Tigers rank 25th nationwide in turnover margin (+2) and lead the FBS in red-zone scoring efficiency (100%). Their defense holds opponents to just 20.8% conversion on third downs. Key players include QB Beau Pribula (617 yards, 5 TDs, 0 INTs) and RB Ahmad Hardy (212 yards, 2 TDs).

Standout Players and Key Injuries

Louisiana:
- Bill Davis and Zylan Perry lead the ground game, while Daniel Beale provides a spark at QB after stepping in due to Walker Howard’s injury.
Missouri:
- QB Beau Pribula has been efficient and turnover-free through two games. Running back Ahmad Hardy and receiver Kevin Coleman Jr. (174 yards) anchor Missouri’s offense.

No significant injuries beyond Howard’s oblique issue have been reported for either side.

Prediction Reasoning

This game represents a classic SEC versus Group-of-Five matchup. Missouri's advantage in depth, execution in scoring territory, and proven clutch performance gives them a clear upper hand. Louisiana’s offense, while grounded, lacks elite consistency and will face a significant challenge against Missouri’s discipline and momentum.

Final Score Projection: Missouri 38, Louisiana 17

Best Bets:

Missouri ATS
Total Over up to 55 points

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