Notre Dame vs Purdue Picks and Predictions for Saturday, September 26th, 2026

By: Cameron Ross Published 09/25/2026, 02:16 PM ET

Notre Dame vs Purdue Game Information

The Notre Dame Fighting Irish will be on the road Saturday in West Lafayette, IN, against the Purdue Boilermakers. Notre Dame is the #3-ranked team in the nation, undefeated this season coming into Saturday after a 17-point victory last week. The Purdue Boilermakers return home 1-2 on the year, riding a 2-game skid after a 14-point road loss to UCLA last week. Stay in the news with our College Football Picks.

Notre Dame Preview

CJ Carr leads Notre Dame this season with 726 yards and 6 touchdowns on 53 completions without throwing an interception. Nolan James Jr. leads the Fighting Irish with 169 yards and 3 touchdowns on 39 rushing attempts, while Aneyas Williams has added 144 yards and 3 scores on 38 carries. Micah Gilbert leads the receiving corps with 251 yards and 1 touchdown on 13 catches. Jordan Faison has contributed 173 yards and 2 scores on 13 receptions. Nolan James Jr. has added 7 catches for 73 yards and 1 score.

Purdue Preview

Ryan Browne leads Purdue this season with 1,024 yards and 7 touchdowns on 74 completions. Browne has thrown only 1 interception through 101 attempts. Fame Ijeboi leads the Boilermakers with 248 yards and 6 touchdowns on 55 carries. Asaad Waseem leads the receiving attack with 321 yards and 1 score on 20 catches. Xavier Townsend has added 267 yards and 2 touchdowns on 19 receptions, while Chauncey Magwood has contributed 110 yards and 1 score on 8 catches.

Notre Dame vs Purdue Pick

Notre Dame should have little difficulty moving the football against a Purdue defense that allowed 52 points against UCLA. However, the Boilermakers possess enough offensive firepower to make covering 27.5 points difficult. Browne has surpassed 1,000 passing yards while committing only 1 turnover, and Ijeboi gives Purdue a productive option on the ground. Notre Dame should control the matchup and secure a comfortable win, but Purdue can score enough to cover the large spread and help push the total over.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.
  • Pick: Purdue Boilermakers +27.5
  • Secondary: Over 57.5

Final Score Prediction: Notre Dame Fighting Irish win 42-24.

Betting on College Football?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.

FanDuel Sportsbook

New Users – Get $250 in Bonus Bets when you wager $5 for 5 days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Get $350 in Bonus Bets when you wager $5 for 7 days ($50 Bonus Bets per day)
Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 5 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB

DraftKings Sport

New DraftKings Customer: SPEND $5, GET $200 IN BONUSES

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Requirement New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES ($50 in Bonus Bets every 7 days for 21 days)*
Cashable No

To be eligible for DraftKings Sportsbook and the Promotion, you must be physically located in AR, AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA (select parishes), MA, MD, ME, MI, MO, NC, NJ, NH, NY, OH, OR, PA, PR (residents only), TN, VA, VT, WY, WV, CA-ONT or CA-AB (each an “Eligible Jurisdiction” or, collectively, the “Eligible Jurisdictions”). Must be 21+ years of age or older (18+ if in DC/NH/PR/WY/CA-AB) (19+ in CA-ONT). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA) Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: Promos | DraftKings Sportsbook . Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.

Boise State vs Western Michigan Picks and Predictions for Saturday, September 26th, 2026

Boise State vs Western Michigan Picks and Predictions for Saturday, September 26th, 2026

Boise State vs Western Michigan Game Information The Boise State Broncos will travel to Kalamazoo on Saturday for a 3:30 PM matchup inside Waldo Stadium...

Los Angeles Rams vs Denver Broncos Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

Rams vs Broncos prediction

The Los Angeles Rams head to Mile High to face the Denver Broncos in a matchup that looks like a potential photo finish, and this...

Las Vegas Raiders vs New Orleans Saints Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

Ravens vs Saints prediction

The Las Vegas Raiders and New Orleans Saints meet in a matchup between two of the hottest teams against the spread, and this Raiders vs...

Baltimore Ravens vs Dallas Cowboys Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

Ravens vs Cowboys prediction

The Baltimore Ravens and Dallas Cowboys meet at Maracana Stadium in Rio de Janeiro, Brazil, in what figures on paper to be one of the...

Minnesota Vikings vs Tampa Bay Buccaneers Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

Vikings vs Buccaneers picks

The Minnesota Vikings travel to Tampa to face the Buccaneers in a matchup between one of the hottest teams in football and one of the...

Arizona Cardinals vs San Francisco 49ers Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

Cardinals vs 49ers prediction

The Arizona Cardinals travel to Levi's Stadium in Santa Clara to face the San Francisco 49ers in an NFC West matchup where the two teams...

Video: Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Video: Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview

A broad list of handicappers publishing premium picks across NFL, NBA, CBB, NHL, CFL, and soccer, including Rob Vincilleti, Ben Burns, Mike Lundin, Sean Higgs, Ross Benjamin, and algorithmic teams like Advanced Sports AI.

Ben Burns Billy Coleman Bruce Marshall Bryan Power Chip Chirimbes David Delano David Hess Jackie Mack Jesse Schule Joe Duffy Joseph D'Amico Marc David Mark Ruelle Mark Zinno Mike Fink Mike Lundin Nick Parsons Pro Sports Picks Razor Ray Monohan Ricky Tran Rob Vinciletti Rocky Atkinson Ross Benjamin Sean Higgs Sniper Wes Stephen Nover Steve Seagrave Terry Edelmann The Gold Sheet Tom Macrina Tony Karpinski Trent Bets Will Rogers
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Follow us

Copyright © 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.