Oklahoma vs. South Carolina Picks and Prediction for Saturday October 18, 2025
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On Saturday, the Oklahoma Sooners (5-1) face off against the South Carolina Gamecocks (3-3) at Williams-Brice Stadium in Columbia, South Carolina. The game will be aired on SEC Network. Keep up to date with all the College Football action, with our College Football predictions.
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Game Information for Oklahoma vs South Carolina
- October 18, 2025
- 12:45pm EST
- Williams-Brice Stadium
- SEC Network
- 73° sunny at start time
South Carolina Form & Recent Results
South Carolina heads into this matchup hoping to rebound after a tough stretch. The Gamecocks are currently riding a one-game losing streak and have lost three of their last five games. In their game last week, they fell short against LSU with a 20-10 defeat. Quarterback LaNorris Sellers struggled a bit in that game, completing 15 of his 27 pass attempts but throwing an interception. Over the course of the season, Sellers has racked up 1,010 passing yards, showing flashes of his potential. On the ground, the Gamecocks rely on Rahsul Faison, who leads the team with 231 rushing yards, while fellow running back Matt Fuller has contributed 154 yards. In the receiving corps, Vandrevius Jacobs has emerged as a top target, hauling in 341 yards so far this season. Defensively, South Carolina has given up an average of 20.6 points per game in their last five games. Offensively, they have posted 22.3 points per game throughout the season. As they prepare to host Oklahoma, the Gamecocks will be looking for a spark on both sides of the ball in hopes of pulling off an upset in front of their home crowd.
Oklahoma Form & Recent Results
Oklahoma comes into this matchup hoping to bounce back after a tough loss, as they saw their four-game winning streak snapped last week against Texas in the Allstate Red River Rivalry. During that game, the Sooners struggled offensively and fell 23-6 in a surprising upset. Quarterback John Mateer completed 20 of his 38 passes but was picked off three times by the Longhorns’ defense. Despite the rough outing, Mateer has put together a solid season so far, throwing for 1,417 yards. The Sooners have relied on a committee approach in their running game, with Tory Blaylock leading the way on the ground with 290 rushing yards. Through the air, wide receiver Isaiah Sategna III has emerged as a favorite target, hauling in 420 yards worth of receptions, while tight end Jaren Kanak has contributed 348 receiving yards. Offensively, Oklahoma has been fairly consistent, averaging 28 points per game over their past five contests. On the season as a whole, they’re putting up just over 29 points per game. With their recent setback fresh on their minds, the Sooners are motivated to regroup and return to their winning ways as they look to get their season back on track.
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Key Players for South Carolina and Oklahoma
- Oklahoma QB John Mateer: 115/179, 6 TD, 6 INT
- South Carolina QB LaNorris Sellers: 73/114, 4 TD, 2 INT
Betting Odds & Market Overview:
- OU -4.5; O/U 42.5
South Carolina vs Oklahoma Picks and Prediction
Last week, Oklahoma suffered an upset defeat at the hands of Texas, shaking up their momentum. Now, the team is eager to bounce back as they travel to take on South Carolina. Meanwhile, the Gamecocks will be looking to capitalize on Oklahoma’s recent struggles, aiming to hand the Sooners a second straight loss and earn a statement win on their home field. Final Score Prediction, Oklahoma Sooners win but fail to cover the spread, 22-18.
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