Old Dominion vs South Florida Picks and Predictions for Wednesday, December 17, 2025
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The Old Dominion Monarchs play the South Florida Bulls in the StaffDNA Cure Bowl. Old Dominion enters at 9–3 after a 27–10 win over Georgia State, while South Florida comes in at 9–3 following a 52–3 victory over Rice. Cash your card with our college football picks.
Old Dominion vs South Florida Game Information
- Date: December 17, 2025
- Time: 5:00 PM ET
- Location: Camping World Stadium, Orlando, FL
- TV: ESPN
Old Dominion Monarchs Outlook
Old Dominion finished the regular season at 9–3, securing a 27–10 win over Georgia State in its final outing. Colton Joseph completed 173 passes for 2,624 yards and 21 touchdowns and also led the ground game with 1,007 rushing yards and 13 scores. Tre’ Brown III paced the receivers with 751 yards. The Monarchs also received steady contributions from Ja’Cory Thomas, who added 674 receiving yards, and running back Trequan Jones, who totaled 736 rushing yards.
Jerome Carter finished as the leading tackler with 72 and led the secondary with four interceptions, and Jeremy Mack Jr. posted 4.5 sacks. Old Dominion looks to continue its strong defensive play and make use of Joseph’s dual-threat capabilities in this bowl matchup.
South Florida Bulls Outlook
South Florida matched Old Dominion’s record at 9–3, closing the season with a 52–3 win over Rice. Quarterback Byrum Brown threw for 3,158 yards and 28 touchdowns and added 1,008 rushing yards with 14 more scores. Keshaun Singleton led the receiving corps with 877 yards and eight touchdowns. The Bulls also relied on Jeremiah Koger, who produced 529 receiving yards, and Nykahi Davenport, who ran for 603 yards and seven touchdowns.
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Linebacker Mac Harris recorded 100 tackles to anchor the defense and had a team-high six sacks. South Florida’s offense proved consistent throughout the season with a strong mix of big-play production and sustained drives, while the defense made enough stops. The Bulls enter bowl season with confidence after a dominant final month.
Monarchs vs Bulls Prediction
South Florida has the stronger passing attack and a quarterback capable of impacting the game on the ground and through the air. Old Dominion has been solid defensively and carries momentum after several convincing wins, but the Bulls’ offensive balance gives them an advantage over four quarters. Final score prediction: South Florida Bulls win and cover ATS 35-28. Betting on sports and on South Florida is easy, but even easier if you use the best sportsbooks. Make sure you know about how the fans are looking on prediction markets for Old Dominion with the Novig promo code. Make sure when you place your bet on Old Dominion vs South Florida you are using the BetMGM bonus code.
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Best Picks
- South Florida -3
- Over 53.5
