Ole Miss vs Kentucky Picks and Prediction for Saturday September 6 2025

By: Cameron Ross Published 09/02/2025, 11:26 PM ET

Ole Miss Preview

The Ole Miss Rebels are the number 21-ranked team in the nation heading into Kentucky this week for a Week 2 SEC matchup. Ole Miss is 1-0 this year following a 56-point blowout home win over Georgia State in week one. Ole Miss dominated a week ago, giving up just seven points on 260 total yards and forcing 1 turnover in the game period. The Rebels offense rolled as well, scoring 63 points, including 38 in the second half, on 695 total yards. Stay up to date with our College Football Picks.

Austin Simmons did the work for Ole Miss a week ago, leading the team with 340 yards and three scores on 20 completions. Kewan Lacy boasted a team high of 108 yards and three touchdowns on 16 carries. Logan Diggs chipped in seven carries for 91 yards and one score. Harrison Wallace the third led the team with 130 yards and one touchdown on five catches.

Kentucky Preview

Kentucky will stay at home this week undefeated on the year, following an 8-point victory against Toledo to start the season. Defensively, Kentucky did just enough week ago, giving up 16 points on 329 yards and forcing 1 turnover in the game. Offensively, Kentucky did the work, scoring 24 points, including fourteen in the fourth quarter, on 305 total yards.

Zach Calzada led the way for the Kentucky offense a week ago, completing 10 passes for 85 yards in the game. Dante Dowdell led the team with 129 yards and one touchdown on 14 carries. Seth McGowan chipped in 18 carries for 78 yards and one score as well. Josh Kattus led the team with three catches for 43 yards in the game.

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Ole Miss vs Kentucky Pick

Both teams come into this week undefeated and will look to make their mark in the first conference matchup of the season. Ole Miss is the far better team, and it will show Saturday. Look for Ole Miss to rely on their depth all over the field to overwhelm a good Kentucky team in week two. Take the Rebels this week to do enough to get the road win as they cover the number in Lexington. Final Score Prediction, Ole Miss Rebels win and cover 35-21.

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