Oregon vs Oklahoma State Picks and Predictions for Saturday, September 12th, 2026

By: Cameron Ross Published 09/10/2026, 11:34 AM ET

Oregon vs Oklahoma State Game Information

The Oregon Ducks will be on the road this Saturday, playing the Oklahoma State Cowboys at Boone Pickens Stadium in Stillwater, OK, at 12:00 PM. Oregon comes into Game 2 of the year undefeated and ranked No. 6 in the nation following a 34-27 victory against Boise State last week. Oklahoma State remains at home this week, winless after opening the season with a 24-10 loss against Tulsa.  Keep up with our College Football Picks.

Oregon Preview

Defensively, Oregon had an up-and-down performance last week, giving up 27 points despite holding Boise State to just 274 total yards. Offensively, the Ducks moved the ball extremely well, scoring 34 points on 497 total yards. Dante Moore led the way for the Oregon offense, completing 28 passes for 378 yards and 3 touchdowns. Jordon Davison was the top ball carrier with 90 yards and 1 touchdown on 12 carries. Jeremiah McClellan led the team with 150 yards and 1 touchdown on 6 receptions. Dakorien Moore added 93 yards and 1 touchdown on 6 grabs.

Oklahoma State Preview

Defensively, Oklahoma State struggled to slow down Tulsa last week, giving up 24 points on 361 yards in the season-opening loss. Offensively, the Cowboys moved the ball for 368 total yards but scored just 10 points after turning the ball over 4 times. Drew Mestemaker led the way for the Oklahoma State offense, completing 29 passes for 241 yards and 1 touchdown but threw 2 interceptions. Caleb Hawkins was the top ball carrier with 79 yards on 18 carries. Wyatt Young led the team with 84 yards on 8 catches. 

Oregon vs Oklahoma Pick

Oregon has too much offensive firepower for Oklahoma State to contain throughout this matchup. The Ducks should be able to create explosive plays through the air while using their speed to stretch the Cowboys’ defense in every direction. Oklahoma State may find some early success, but it will struggle to keep pace once Oregon settles into the game. Take the Ducks to pull away for the convincing road victory and cover.

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  • Pick: Oregon Ducks -23.5
  • Secondary: Under 57.5

Final Score Prediction: Oregon Ducks win and cover 42-7

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