Oregon vs USC Picks and Predictions for Saturday, September 26th, 2026

Oregon vs USC Game Information

The Oregon Ducks will be on their second road trip of the season this week, facing the USC Trojans at Los Angeles Memorial Coliseum in Los Angeles, CA, at 7:30 PM. Oregon is ranked #20 in the nation, 2-1 this year, after an 84-point blowout win over Portland State last week. The USC Trojans returned home Saturday undefeated at 4-0 and ranked No. 12 in the nation after a 7-point road win over Rutgers last week. Keep up with our College Football Picks.

Oregon Preview

Dante Moore leads Oregon this season with 849 yards and 9 touchdowns on 61 completions without throwing an interception. Dylan Raiola has completed all 11 of his passes for 124 yards and 3 scores. Jordon Davison leads the Ducks with 194 yards and 4 touchdowns on 33 carries, while Dierre Hill Jr. has added 121 yards and 1 score on 27 attempts. Evan Stewart leads the receiving corps with 222 yards and 2 touchdowns on 15 catches. Dakorien Moore has contributed 192 yards and 3 scores on 11 receptions.

USC Preview

Jayden Maiava leads USC this season with 1,173 yards and 12 touchdowns on 87 completions. Maiava has thrown only 1 interception through 115 attempts. King Miller leads the Trojans with 338 yards and 3 touchdowns on 64 carries, while Waymond Jordan has added 188 yards and 1 score on 37 attempts. Kayden Dixon-Wyatt leads the team with 258 yards and 2 touchdowns on 18 catches. Trent Mosley has contributed 255 yards and 4 scores on 13 receptions.

Oregon vs USC Pick

Both quarterbacks have played extremely efficient football, combining for 21 touchdown passes and only 1 interception. USC has the home-field advantage and enough offensive weapons to trade scores throughout the game, but its defense struggled to put away Rutgers. Oregon owns the stronger defensive unit and should have more success controlling the line of scrimmage. Moore has protected the football and consistently found different receivers, making it difficult for USC to focus on one option. Look for Oregon to make one or two additional defensive stops and cover the short road spread in a high-scoring matchup.

• Pick: Oregon Ducks -2.5
• Secondary: Over 62.5

Final Score Prediction: Oregon Ducks win and cover 38-31.

Betting on College Football?

• Bet with other College Football fans at the best sportsbooks
• Sign up today and get started with the latest college football sportsbook promos

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code

Claim Bonus

Signup Promo Recommended BetMGM Sport Bonus

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.

New Users – Get $250 in Bonus Bets when you wager $5 for 5 days

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer FanDuel Sportsbook Bonus

Requirement New Users – Get $350 in Bonus Bets when you wager $5 for 7 days ($50 Bonus Bets per day)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 5 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB

New DraftKings Customer: SPEND $5, GET $200 IN BONUSES

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer DraftKings Sport Bonus

Min. Deposit $5

Requirement New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES ($50 in Bonus Bets every 7 days for 21 days)*

Cashable No

To be eligible for DraftKings Sportsbook and the Promotion, you must be physically located in AR, AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA (select parishes), MA, MD, ME, MI, MO, NC, NJ, NH, NY, OH, OR, PA, PR (residents only), TN, VA, VT, WY, WV, CA-ONT or CA-AB (each an “Eligible Jurisdiction” or, collectively, the “Eligible Jurisdictions”). Must be 21+ years of age or older (18+ if in DC/NH/PR/WY/CA-AB) (19+ in CA-ONT). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA) Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: Promos | DraftKings Sportsbook . Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.

Boise State vs Western Michigan Picks and Predictions for Saturday, September 26th, 2026

Boise State vs Western Michigan Game Information The Boise State Broncos will travel to Kalamazoo on Saturday for a 3:30 PM matchup inside Waldo Stadium...

Los Angeles Rams vs Denver Broncos Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

The Los Angeles Rams head to Mile High to face the Denver Broncos in a matchup that looks like a potential photo finish, and this...

Las Vegas Raiders vs New Orleans Saints Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

The Las Vegas Raiders and New Orleans Saints meet in a matchup between two of the hottest teams against the spread, and this Raiders vs...

Baltimore Ravens vs Dallas Cowboys Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

The Baltimore Ravens and Dallas Cowboys meet at Maracana Stadium in Rio de Janeiro, Brazil, in what figures on paper to be one of the...

Minnesota Vikings vs Tampa Bay Buccaneers Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

The Minnesota Vikings travel to Tampa to face the Buccaneers in a matchup between one of the hottest teams in football and one of the...

Arizona Cardinals vs San Francisco 49ers Picks, Prediction, Odds, and Line Movement for Sunday September 27 2026

The Arizona Cardinals travel to Levi's Stadium in Santa Clara to face the San Francisco 49ers in an NFC West matchup where the two teams...

Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions

Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview