South Carolina State vs South Florida Pick and Prediction for Saturday, September 10, 2025

By: Ricky Mackenzie Published 09/14/2025, 11:37 PM ET

South Carolina State Preview

South Carolina State heads to Raymond James Stadium to face South Florida in a matchup featuring two programs with something to prove. Get our free College Football Picks all season long! The Bulldogs are 2-1 after a wild 55-41 win over Bethune-Cookman, while the Bulls are looking to bounce back following a humbling 49-12 loss to fifth-ranked Miami.

South Florida Preview

South Florida opened the season strong but was exposed last week in nearly every phase. The offense moved the ball early but couldn’t finish drives, and the defense wore down against elite speed. Returning home should provide a much-needed reset, especially against a defense that just gave up 41 points at home.

The Bulldogs don’t lack confidence. Their offense has put up 40-plus in back-to-back weeks, and they won’t shy away from pushing tempo. Quarterback play has been efficient, and the ground game continues to carry the load. But this will be their biggest defensive test to date.

If South Florida can re-establish the run game and clean up the red-zone execution, they’ll have the tools to control the pace. Depth and size favor the home sideline, but if South Carolina State starts fast, this could get uncomfortable quickly. Execution in the second half will likely swing the result.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

South Florida vs South Carolina State Pick

South Florida’s athleticism and home-field edge should be enough to overcome any early nerves or hangover from last week. Expect the defense to settle in and make key stops while the offense finds balance against a leaky front. Final Score Prediction, South Florida Bulls win 38-24.

Betting on College Football?

Bet with other College Football fans at the best sportsbooks
Sign up today and get started with the latest college football sportsbook promos

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.