South Carolina vs Alabama Picks and Prediction for Saturday, September 26, 2026

By: David Anicetti Published 09/22/2026, 10:20 PM ET

The South Carolina Gamecocks visit the 8th-ranked Alabama Crimson Tide on Saturday, September 26, at Bryant-Denny Stadium in Tuscaloosa, with the opening kickoff scheduled for 7:00 PM ET on ESPN. The South Carolina Gamecocks are 2-1 overall and 0-1 in the SEC after a 41-34 loss to Mississippi State. The Alabama Crimson Tide are 3-0 overall and 1-0 in the SEC after beating Florida State 50-36. Follow Saturdayโ€™s action with our free NCAAF picks.

South Carolina Gamecocks Preview

South Carolina is averaging 45.3 points through three games, with 248.7 passing yards and 277.3 rushing yards per game. LaNorris Sellers has completed 54 of 86 passes for 648 yards, five touchdowns and three interceptions. Sellers has also rushed for 172 yards and one score. Matt Fuller leads the ground attack with 272 yards and three touchdowns while averaging 7.2 yards per carry. Donovan Murph leads the receiving group with 136 yards and two touchdowns.

The Gamecocks are allowing 16.7 points per game, although Mississippi State scored 41 in South Carolinaโ€™s SEC opener. South Carolina has recorded eight sacks and two interceptions. Anthony Addison leads the pass rush with two sacks, while Jโ€™Zavien Currence and Tomiwa Durojaiye have one each. Justin Okoronkwo leads the defense with 19 tackles, and Peyton Williams has 13 tackles and an interception. The Gamecocks have not recorded a fumble recovery through three games.

Injuries: OG J. Peak and QB Lucian Anderson III are questionable with undisclosed injuries. DL Dylan Stewart (back), WR J. Sellers (lower body) and WR J. Gibson (lower body) are out.

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Alabama Crimson Tide Preview

Alabama is averaging 47.7 points through its 3-0 start, scoring at least 45 points in every game. Keelon Russell has completed 57 of 83 passes for 764 yards, four touchdowns and two interceptions. The Crimson Tide have rushed for 629 yards and 11 touchdowns, averaging 209.7 yards per game and 5.0 yards per carry. Daniel Hill leads the backfield with 210 yards and three touchdowns, while Ryan Coleman-Williams has 235 receiving yards and one score.

The Crimson Tide are allowing 21 points per game, holding East Carolina to 10 and Kentucky to 17 before allowing 36 against Florida State. Alabama has 10 sacks and five interceptions through three games. Devan Thompkins leads the team with three sacks, while Caleb Woodson and Terrance Green have two each. Woodson also leads Alabama with 18 tackles. Luke Metz, Yhonzae Pierre, Red Morgan, Bray Hubbard and Ivan Taylor have each recorded an interception.

Injuries: WR A. Walker is questionable with an undisclosed injury. WR N. Rogers (leg) and RB A. Dear (leg) are out.

South Carolina vs Alabama Prediction

Both offenses have produced big numbers, with South Carolina averaging 45.3 points and Alabama averaging 47.7. The Gamecocks have been especially productive on the ground at 7.0 yards per carry, but Alabama enters with more defensive pressure and takeaways, recording 10 sacks and five interceptions. South Carolinaโ€™s three interceptions from Sellers are also important against an Alabama defense capable of creating turnovers. The Crimson Tide have scored 143 points through three games and will use their balanced offense to pull away at home, but South Carolina has enough rushing production to stay within 13.5 points. Final Score Prediction: Alabama Crimson Tide win but fails to cover the spread, 38-30.

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