South Florida vs. Memphis Picks and Prediction for Saturday, October 25, 2025
Use Code PPWC
South Florida heads to Memphis on Saturday morning for a pivotal American Conference matchup at Simmons Bank Liberty Stadium. Kickoff is scheduled for 12:00 PM ET. The Tigers enter 6-1 overall and 2-1 in league play, while the Bulls sit at 6-1 and perfect in conference action. Memphis is favored by ESPN Analytics, holding a 63.5% chance to win at home. Rivalry week? Bowl season? From underdogs to point spreads, we’ve got your back with free college football picks.
South Florida Preview
South Florida continues to ride momentum from a five-game winning streak, including a dominant 48-13 win over FAU last week. Quarterback Byrum Brown has been at the center of the surge, throwing for 1,439 yards with 13 touchdowns and five interceptions while also adding 364 rushing yards and five scores on the ground. His dual-threat ability has made USF one of the toughest offenses in the AAC to contain, averaging well over 40 points per game across the last month. Running lanes have opened thanks to a strong passing game as well, creating favorable matchups for Brown and Micah Welch.
Memphis Preview
Memphis stumbled for the first time since September with a 31-24 road loss to UAB, a result that snapped a four-game win streak. Quarterback Brendon Lewis continues to lead a balanced offense, posting 1,269 yards through the air with eight touchdowns and four picks. Running back Sutton Smith has been a reliable option, racking up 454 yards and six touchdowns on 70 carries, while wideout Cortez Braham Jr. has hauled in 24 passes for 408 yards and five scores. The Tigers have relied on big plays but will need a sharper passing performance to match the Bulls’ pace.
South Florida vs Memphis Pick
This matchup features two quarterbacks capable of taking over games, but South Florida’s versatility and strength on offense give it a narrow advantage. Memphis has struggled to limit mobile quarterbacks, which could lead to another big day for Brown both as a passer and runner. With the Bulls’ confidence surging and the offense operating at a high level, they have the tools to beat the Tigers in a shootout.
Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Subscribe Now
Prediction: South Florida 38, Memphis 34
Betting on College Football?
- Bet with other College Football fans at the best sportsbooks
- Sign up today and get started with the latest college football sportsbook promos
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!
Best Picks:
- South Florida +3 (road underdog with strong momentum)
- Over 66.5 total points (both offenses clicking behind dual-threat QBs)
- Byrum Brown anytime touchdown scorer
