Southeast Missouri State vs Iowa State Picks and Predictions for Saturday, September 5th, 2026

Southeast Missouri State vs Iowa State Game Information

The Southeast Missouri State RedHawks will play their second consecutive road game Saturday afternoon when they visit Ames, Iowa, for a 1:00 PM matchup against the Iowa State Cyclones at Jack Trice Stadium. Southeast Missouri State struggled throughout the 2025 season, finishing 4-8 overall after losing 4 of its final 5 games, though they come into Saturday undefeated following a 2-point road win last week. Iowa State opens its 2026 campaign Saturday after putting together an 8-4 record last year. The Cyclones closed the season with 3 straight victories, including a 20-13 road win against Oklahoma State in their finale. Stay in the loop with our College Football Picks.

Southeast Missouri State Preview

Southeast Missouri State did just enough on the offensive side a week ago, scoring 23 points on 327 total yards. Defensively, Southeast Missouri State held on, giving up 21 points on 346 yards but forcing 1 turnover in the win. Braylen Ragland led the way for the Southeast Missouri State offense last week, completing 26 passes for 274 yards and 1 score. Khyair Spain led the way on the ground with 66 yards and 1 touchdown on 17 carries. John Anthony Jr. added a team-high 88 yards and 1 touchdown on 6 receptions.

Iowa State Preview

With Rocco Becht transferring to Penn State after last season, the Cyclones entered the transfer portal for a new quarterback. Jaylen Raynor will be at the helm for Iowa State this season after completing 333 passes for 3361 yards and 19 scores last season at Arkansas State. Aiden Flora is the top returning ball carrier for Iowa State this season after only 58 yards and 1 touchdown on 4 carries a year ago.

South East Missouri State vs Iowa State Pick

Iowa State has the superior roster and should be able to dictate the action on both sides of the ball Saturday. Southeast Missouri State will struggle to generate consistent offense, while the Cyclones should repeatedly capitalize on favorable field position. Look for Iowa State to build an early lead and continue extending it, leading to a dominant home victory and cover.

• Pick: Iowa State Cyclones -29.5
• Secondary: Under 53.5

Final Score Prediction: Iowa State Cyclones win and cover 42-3.

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