Southern Illinois vs Illinois Picks and Predictions for Saturday, September 19th, 2026

Southern Illinois vs. Illinois Game Information

The Southern Illinois Salukis will be on the road Saturday for a 2:00 PM matchup inside Gies Memorial Stadium in Champaign against the Illinois Fighting Illini. Southern Illinois enters the game at 2-1 after recording a 14-point victory over Southeast Missouri State last week. Illinois is 1-1 following a narrow 4-point loss to Duke. Stay in the action with our College Football Picks.

Southern Illinois Preview

Southern Illinois has used 2 quarterbacks this season, as Jake Curry leads the team with 321 yards and 4 touchdowns on 27 completions. DJ Williams has added 305 yards and 1 touchdown on 20 completions, along with 113 yards and 4 scores on 12 carries. Chandler Chapman leads the Southern Illinois backfield with 279 yards on 52 attempts. Curry has contributed another 53 yards and 1 touchdown on 18 carries, while Edward Robinson has recorded 51 yards on 15 attempts. Kyle Thomas leads the Salukis through the air with 185 yards and 1 touchdown on 8 catches. Allen Middleton has added 128 yards and 1 score on 12 receptions, while Markell Quick has contributed 71 yards on 5 grabs.

Illinois Preview

Katin Houser is leading the Illinois offense this season with 453 yards and 6 touchdowns on 37 completions. Houser has also added 47 yards and 1 score on 7 rushing attempts. Ca’Lil Valentine leads the Illinois backfield with 144 yards and 1 touchdown on 29 carries, while Aidan Laughery has contributed 66 yards on 18 attempts. Collin Dixon has been the Fighting Illini's top target, with 236 yards and 5 touchdowns on 17 catches. Hudson Clement has added 71 yards on 7 receptions, while Ty Robinson has contributed 67 yards and 1 touchdown on 3 grabs. Laughery has also caught 2 passes for 23 yards out of the backfield.

Southern Illinois vs Illinois Pick

Southern Illinois has enough offensive talent to move the football occasionally, especially with Williams creating plays as both a passer and runner. However, Illinois owns a clear advantage in size, speed, and depth at nearly every position. Houser has thrown 6 touchdowns through 2 games and should find plenty of favorable matchups against the Southern Illinois secondary. The Salukis could score enough to avoid a complete shutout, but slowing Illinois for 4 quarters will be extremely difficult. Look for the Fighting Illini to establish control early, build a comfortable halftime advantage, and continue adding points with their reserves. Illinois should earn the dominant home victory and cover the large spread.

• Pick: Illinois -38.5
• Secondary: Over 55.5

Final Score Prediction: Illinois 52, Southern Illinois 10

Betting on College Football?

• Bet with other College Football fans at the best sportsbooks
• Sign up today and get started with the latest college football sportsbook promos

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code

Claim Bonus

Signup Promo Recommended BetMGM Sport Bonus

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, Massachusetts, New York, Ontario, or Puerto Rico.

New Users – Get $350 in Bonus Bets when you wager $5 for 7 days

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer FanDuel Sportsbook Bonus

Requirement New Users – Get $350 in Bonus Bets when you wager $5 for 7 days ($50 Bonus Bets per day)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelpLineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-8HOPE-NY or text HOPENY (467369) (NY). 21+ (18+ D.C., KY, WY) and present in select states (for KS, in affiliation with Kansas Star Casino). First online real money wager only. Min $5 wager required for 7 consecutive days.$5 first deposit required. Bonus issued as nonwithdrawable bonus bets which expire 7 days after receipt. Restrictions apply. See terms at sportsbook.fanduel.com. Call 1-877-770-7867 (LA). ™/© 2026 MLB

New DraftKings Customer: SPEND $5, GET $200 IN BONUSES

Show Bonus Code

Claim Bonus

Signup Promo Hot Offer DraftKings Sport Bonus

Min. Deposit $5

Requirement New DraftKings Customer Offer: SPEND $5, GET $200 IN BONUSES ($50 in Bonus Bets every 7 days for 21 days)*

Cashable No

To be eligible for DraftKings Sportsbook and the Promotion, you must be physically located in AR, AZ, CO, CT, DC, IA, IL, IN, KS, KY, LA (select parishes), MA, MD, ME, MI, MO, NC, NJ, NH, NY, OH, OR, PA, PR (residents only), TN, VA, VT, WY, WV, CA-ONT or CA-AB (each an “Eligible Jurisdiction” or, collectively, the “Eligible Jurisdictions”). Must be 21+ years of age or older (18+ if in DC/NH/PR/WY/CA-AB) (19+ in CA-ONT). GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA) Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets. Stake removed from payout. Reward issued as $50 in Bonus Bets every 7 days via click-to-claim for 21 days. Bonus Bets and click-to-claims expire 7 days (168hrs) after issuance. Terms: Promos | DraftKings Sportsbook . Ends 9/20/26 at 11:59 PM ET. Sponsored by DK.

Seattle Storm vs Golden State Valkyries Picks, Prediction, Odds, and Line Movement for Saturday September 19 2026

The Seattle Storm visit the Golden State Valkyries on Saturday night at Chase Center, and this lopsided West Coast matchup stands out among this weekend's...

Chicago Sky vs Atlanta Dream Picks, Prediction, Odds, and Line Movement for Saturday September 19 2026

The Chicago Sky travel to State Farm Arena to face the Atlanta Dream on Saturday night, and this lopsided Eastern Conference matchup is one of...

Phoenix Mercury vs Dallas Wings Picks, Prediction, Odds, and Line Movement for Saturday September 19 2026

The Phoenix Mercury visit the Dallas Wings on Saturday afternoon at College Park Center, and this matchup offers plenty to unpack for anyone browsing WNBA...

2026 Midterm Odds: Democrats 60% Senate, 90% House | Kalshi Promo Code

Prediction-market prices moved further toward Democratic control of Congress Friday, with traders now pricing Democrats at approximately 60% to control the Senate and roughly 90%...

Washington Commanders vs Dallas Cowboys Picks, Prediction, Odds, and Line Movement for Sunday September 20 2026

The jury remains out on the latest roll of the dice by Jerry Jones, who authorized a complete defensive remake after the Cowboys ranked at...

Seattle Seahawks vs Arizona Cardinals Picks, Prediction, Odds, and Line Movement for Sunday September 20 2026

What a difference from a week ago, when the Seahawks were on top of the world as defending champs and the Cardinals were regarded as...

Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions

Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview