Stanford vs BYU Picks and Predictions for Saturday September 6 2025

By: Kim Smith Published 09/02/2025, 02:50 PM ET

Stanford at BYU Preview

The Stanford Cardinal face the BYU Cougars in a Week 2 college football matchup on September 6, 2025, at LaVell Edwards Stadium in Provo, Utah. Kickoff is set for 9:00 p.m. EST, airing on ESPN2. BYU is listed as a 14.5-point favorite with a moneyline of -600, and the over/under is set at 51.5 points, per BetMGM Sportsbook. This non-conference clash pits a Stanford team looking to rebound from a Week 1 loss against a BYU squad riding momentum from a strong opener. Boost your betting edge with expert College Football Betting Picks for top insights and winning strategies.

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Stanford Analysis

Stanford opened the 2025 season at 0-1, falling 23-20 to Hawaii in Week 0, a game where they struggled to close out despite a late rally. The Cardinal finished 2024 at 3-9 overall, showing flashes of potential but lacking consistency under coach Troy Taylor. Their road performance last season (1-5) highlights the challenge of facing BYU in Provo’s high altitude.

Stanford’s offense averaged 20 points and 334.6 yards per game in Week 0, with quarterback Ashton Daniels throwing for 187 yards and a touchdown while adding 44 rushing yards. Running back Sedrick Irvin contributed 62 yards. Defensively, the Cardinal allowed 23 points and 356 yards against Hawaii, with vulnerabilities in the secondary (7.8 yards per pass attempt in 2024) that BYU’s passing attack could exploit.

BYU Analysis

BYU started 2025 at 1-0, defeating FCS Southern Utah 38-10 in Week 1. The Cougars showcased a balanced offense and a stout defense, limiting their opponent to 198 total yards. In 2024, BYU went 10-3, including a 6-0 home record, and their dominant Week 1 performance under coach Kalani Sitake suggests they’re primed for another strong season.

The Cougars’ offense averaged 38 points and 426 yards in Week 1, led by quarterback Jake Retzlaff, who threw for 243 yards and two touchdowns. Running back LJ Martin added 97 yards and a score. Defensively, BYU allowed 10 points and 3.9 yards per play, with linebacker Jack Kelly recording nine tackles and a sack, building on their 2024 average of 22.7 points allowed per game.

Standout Players and Key Injuries

For Stanford, quarterback Ashton Daniels is the offensive leader, showcasing dual-threat ability with 2,147 passing yards and 614 rushing yards in 2024. Wide receiver Elic Ayomanor, with 62 catches for 837 yards last season, is a key target. Linebacker Gaethan Bernadel led with 78 tackles. For BYU, quarterback Jake Retzlaff drives the offense, and wide receiver Chase Roberts (45 catches, 698 yards in 2024) is a playmaker. Linebacker Jack Kelly anchors the defense with his pass-rushing prowess.

Stanford lists running back Chris Davis Jr. as questionable with a hamstring injury, potentially limiting their ground game. BYU reports no major injuries, entering Week 2 at full strength.

#	Handicapper	Profit
1	Earle Sports Bets	+2,298.00
2	Rob Vincilleti	+2,063.00
3	David Hess	+1,865.00
4	Ross Benjamin	+1,830.00
5	Dan Kaiser	+986.00

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Prediction Reasoning

BYU’s home dominance, with a 6-0 record at LaVell Edwards Stadium in 2024, and their balanced attack give them a significant edge. Retzlaff’s efficiency and Martin’s rushing ability should exploit Stanford’s shaky run defense, which allowed 4.8 yards per carry in Week 0. The Cardinal’s offense, led by Daniels, may find some success against BYU’s secondary, but their defensive inconsistencies and road struggles make an upset unlikely. The Cougars’ depth and high-altitude advantage should lead to a comfortable win, though Stanford’s grit could keep the score respectable. Final Score Prediction: BYU 38, Stanford 20.

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