Syracuse vs SMU Picks and Prediction for Saturday, October 4, 2025

By: Cameron Ross Updated 10/03/2025, 11:00 PM ET
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Syracuse vs SMU Information

The Syracuse Orange will be on the road again this week with an ACC matchup inside Gerald J. Ford Stadium against the SMU Mustangs at 3:30 PM. Syracuse has been up and down thus far this season, with three wins and two losses overall, following a 35-point home loss to Duke a week ago to end a three-game winning streak. The SMU Mustangs return home this week with two wins and two losses on the year following the 11-point road loss to TCU in their last outing. Get the edge this weekend with our free college football picks backed by data and trends.

Syracuse Preview

Offensively, Syracuse has been mediocre this season, averaging 31.2 points per game overall, but has averaged just 14.5 points per game during their two losses. Defensively, Syracuse has a mediocre defense, allowing 29 points per game this season, but has given up, on average, 41.5 points per game in its losses. Steve Angeli leads the Syracuse offense this season with 1317 yards and 10 scores on 98 completions. Yasin Willis is the top ball carrier on the team with 233 yards and four scores on 52 carries. Darrell Gill Jr. leads the team with 310 yards and three touchdowns and 14 receptions.

SMU Preview

The SMU Mustangs have been mediocre on both sides of the ball, as the Mustangs are averaging 34.75 points per game this season. Defensively, SMU has been better, allowing 26.5 points per game through four games played.Kevin Jennings leads the SMU offense this season with 1126 yards and 9 scores on 86 completions. T.J. Harden is the top ball carrier on the team with 57 carries for 309 yards and five touchdowns. Romello Brinson leads the team with 19 catches for 365 yards and three touchdowns this season.

Syracuse vs SMU Prediction

The SMU Mustangs are the better team in this matchup, and it will show from the opening minutes this week. Look for the Mustangs to control this game on their home field as they thrive in front of their home fans. Take SMU this week to do the work on both sides as they get the win and cover at home to pick up their third victory of the season. Final Score Prediction, SMU Mustangs win and cover 41-21.

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  • SMU Mustangs -15.5
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