UConn vs Buffalo Picks and Prediction for Saturday, September 27, 2025

By: Cameron Ross Updated 09/27/2025, 01:16 AM ET

UConn vs Buffalo Information

The UConn Huskies will be on the road for the third time this week with a game in Buffalo against the Buffalo Bulls in UB Stadium at 3:30 PM. UConn comes into this week with two wins and two losses overall following a six-point victory against Ball State a week ago to end a 2 game losing streak. Buffalo remains on their home field this week with two wins and two losses following a four-point loss to Troy last time out, ending a 2-game winning streak. Discover which teams the pros are backing with our daily college football picks.

UConn Preview

Offensively, UConn has been solid enough this season, averaging 37.75 points per game overall. Defensively, UConn has been shaky, allowing 27.25 points per game, and has given up an average of 35.5 points per game over its two losses this year. Joe Fagnano leads the UConn offense this season with 1046 yards and six scores on 90 completions. Running back Cam Edwards is the top ball carrier on the team with 500 yards and five scores on 74 carries. Skyler Bell leads all UConn receivers with 445 yards and three touchdowns on 36 catches.

Buffalo Preview

Defensively, Buffalo has had some issues this season, allowing 19.5 points per game overall. Offensively, Buffalo has been better, averaging 25.75 points per game this year. Ta’Quan Roberson leads the Buffalo offense this season with 662 yards and five touchdowns on 59 completions. Al-Jay Henderson is the top ball carrier on the roster with 274 yards and four touchdowns on 72 carries. Victor Snow leads all Buffalo receivers with 206 yards and three scores on 16 receptions.

UConn vs Buffalo Prediction

Both teams have been mediocre this season, coming into this game with one win and two losses apiece. UConn, however, is the better overall team, and it will show this week. Look for the Huskies to control this game on both sides of the ball as they overwhelm Buffalo for 60 minutes, leading to the win and cover on the road in game 5 of the year. Final Score Prediction, UConn Huskies win and cover 35-21.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Best Picks:

UConn Huskies -3

Over 51.5

Betting on College Football?

Bet with other College Football fans at the best sportsbooks
Sign up today and get started with the latest college football sportsbook promos

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.