UNLV vs Wyoming Pick and Prediction for Saturday, October 4, 2025

By: Ricky Mackenzie Updated 10/03/2025, 10:58 PM ET

Anthony Colandrea and the UNLV Rebels will head to War Memorial Stadium to take on Wyoming in a key Mountain West battle. Looking for today’s college football picks? Don’t miss our expert breakdowns. UNLV comes in undefeated at 4-0 following a thrilling 41-38 comeback win over Miami, while Wyoming enters 2-2 after back-to-back losses, including a 37-20 defeat at Colorado.

UNLV Preview

Colandrea threw for 293 yards, two touchdowns, and two interceptions in the win. He continues to lead an offense that thrives under pressure and has found success late in games. Jaden Bradley remains his top target, while running back Jai’Den Thomas adds balance with 118 yards on the ground last week.

Wyoming Preview

Wyoming has struggled to stay consistent offensively. Kaden Anderson went just 11-for-25 with 176 yards in the loss to Colorado, and while Samuel Harris posted 126 yards rushing, the passing attack hasn’t done enough to take pressure off the run game. Defensively, the Cowboys have allowed too many big plays during this recent skid.

Wyoming vs UNLV Prediction

If UNLV controls the tempo and protects the football, their depth and offensive efficiency should carry them through. Wyoming’s best chance is to win in the trenches and slow the game down. Anything less, and the Rebels could pull away late.

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UNLV has been composed in every type of game they’ve faced this year, and their late-game execution continues to be the difference. Wyoming will try to make this physical at home, but Colandrea and the Rebels have too much momentum. Take the Rebels to win and cover the spread. Final Score Prediction, UNLV Rebels win 31-21.

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