Vanderbilt vs Alabama Picks and Prediction for Saturday October 4 2025

By: Eddie Kline Updated 10/03/2025, 11:08 PM ET

Vanderbilt Preview

Bryant-Denny Stadium will play host to a Saturday afternoon college football showdown between the Vanderbilt Commodores and the Alabama Crimson Tide. Maximize your wagers by reading our free college football picks before kickoff. The 16th ranked Commodores (5-0) rank fifth in the SEC Conference in total offense and are averaging 49 points per game. On Saturday, Vanderbilt erupted for 24 points over the final six plus minutes of the first half to earn a 55-35 home victory versus Utah State.

Vanderbilt trailed midway through the second quarter before QB Diego Pavia evened the score at 14 apiece with a six-yard touchdown run. Pavia threw for 321 yards and matched a school record with five passing touchdowns. WR Junior Sherill was on the receiving end of three scores for the Commodores.

Alabama Preview

The Alabama Crimson Tide suffered a season opening loss at Florida State and have rebounded with three straight victories. The 10th ranked Crimson Tide (3-1) are arguably one of the top five most talented teams in the country and are allowing 16.5 points per contest. Last week, Alabama possessed the ball for 35 plus minutes during a 24-21 road victory against fifth ranked Georgia.

Alabama raced out to a 14-0 lead on touchdown passes from Ty Simpson to Germie Bernard and Isaiah Horton. Simpson jumped into the Heisman conversation with 276 passing yards and Horton finished with a game-high 65 receiving yards for the Crimson Tide, who converted 13 of 19 third down attempts.

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Vanderbilt vs Alabama Pick

Vanderbilt QB Diego Pavia has completely changed the perception of the program and a College Football Playoff spot is not out of the realm of possibility. Alabama lost at Vanderbilt last season by a 40-35 final score and will definitely be focused. Look for the Crimson Tide to get the job done in a game that goes over the total. Final Score Prediction, Alabama Crimson Tide win 38-28.

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