Wyoming vs Central MIchigan Picks and Predictions for Saturday, September 19th, 2026

By: Cameron Ross Published 09/18/2026, 10:03 PM ET

Wyoming vs Central Michigan Game Information

The Wyoming Cowboys will take their second road trip of the season this week, facing the Central Michigan Chippewas at Kelly/Shorts Stadium in Mount Pleasant, MI. Wyoming has split its first 2 games of the season coming into Saturday, following an 8-point victory last week. Central Michigan stays on their home field Saturday, 1-1 overall after a narrow 3-point win over Colgate a week ago. For more College Football News, see our College Football Picks.

Wyoming Preview

Tyler Hughes leads Wyoming this season with 279 yards and 2 touchdowns on 30 completions, along with 78 yards and 1 touchdown on 19 carries. Samuel Harris leads the team with 111 yards and 1 touchdown on 27 carries, and Markell Holman has added 94 yards on 12 carries this season. Jake Wilson has been Wyoming's top target this year, with 86 yards on 5 grabs. Charlie Coenen has added 46 yards and 1 touchdown on 5 carries, and Kyle Frendt has chipped in 3 catches for 33 yards and 1 touchdown.

Central Michigan Preview

Angel Flores leads Central Michigan this year with 71 yards on 10 completions and a team-high 149 yards on 32 carries. Vaughn Blue has added 52 yards and 1 Β touchdown on 9 carries, while leading the team with 28 yards on 4 receptions. Nasir Williams has added 23 yards and 1 score on 1 carry. Justin Ruffin Jr. has chipped in a second-best 27 yards on 4 grabs this season. Langston Lewis has added 13 yards on 3 catches.

Wyoming vs Central Michigan Pick

Both teams have similar seasons coming into this matchup, with the same record. Despite those facts, look for Wyoming to do the job on both sides of the ball against a mediocre Central Michigan team. The Cowboys will come into Saturday locked in and control the game from the start, winning on both sides of the ball. Take the Cowboys to do the work as they get the road win in Michigan on Saturday as the underdog.

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  • Pick: Wyoming Cowboys +2.5
  • Secondary: Over 39.5

Final Score Prediction: Wyoming Cowboys win and cover 28-17.

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