Wyoming vs Colorado Pick and Prediction for Saturday, September 20, 2025
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Wyoming vs Colorado Information
The Wyoming Cowboys will be on the road this week for the second time this season, with the game in Colorado at Folsom Field against the Colorado Buffaloes at 10:15 PM. Wyoming has two wins and one loss this season following a 25-point home loss to Utah last time out. The Colorado Buffaloes return home this week with just one win and two losses this year following a 16-point road loss. Houston lost last week. Stay in the action with our College Football Picks.
Wyoming Preview
Offensively, Wyoming has been mediocre this season, averaging just 15.6 points per game overall. Defensively, Wyoming has been stout, holding opponents to just 12.6 points per game through three games played. Kaden Anderson leads the Wyoming offense this season with 535 yards and three touchdowns on 48 completions. Sam Scott is the top ball carrier on the team with 44 carries for 203 yards and one score. Chris Durr Jr. leads the team with 204 yards and two touchdowns on 17 receptions.
Colorado Preview
The Colorado offense has been lackluster this season, averaging 23.6 points per game. Defensively, Colorado has been better, allowing 23.3 points per game through three games played. Ryan Staub leads the Colorado offense this season with 362 yards and three scores on 26 completions. Kaidon Salter has chipped in 30 completions for 261 yards and one score. Simeon Price leads the team with 135 yards and one touchdown on 19 carries. Sincere brown leads the team with six catches for 135 yards and one touchdown.
Wyoming vs Colorado Prediction
Wyoming is having a better year coming into this game, as Colorado has already suffered two losses. Look for Wyoming to play well enough in this game to cover the number, as the Colorado defense will continue to struggle. Look for the Buffs to get the win, but the Cowboys will cover as the total goes well over this week. Final Score Prediction, Colorado Buffaloes win, but the Wyoming Cowboys cover 31-27.
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Best Picks:
- Wyoming Cowboys +13.5
- Over 44
