Arizona Cardinals vs Cincinnati Bengals Picks and Prediction for Saturday, December 27, 2025
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Arizona heads to Paycor Stadium with a 3-12 record and a five-game losing streak, while Cincinnati sits at 5-10 and still has some late-season pride on the line. Kickoff is at 1:00 PM ET on Sunday, December 28 on FOX, with temps around 43 degrees in Cincinnati. DraftKings has the Bengals favored by ‘7 (-115) with a point total of 53.5, and Cincinnati is a heavy moneyline favorite at -380 while Arizona is +300. Ready for kickoff? Ride along with our winning NFL predictions.
Cardinals Outlook
Arizona’s offense has leaned on Jacoby Brissett, who has 2,911 passing yards with 19 TD and 7 INT. The receivers are led by Trey McBride’s huge year with 109 catches for 1,098 yards and 10 TD. The run game has not given the Cardinals much lift, with Michael Carter leading the team at 286 rushing yards. Recent results are disappointing: losses to Atlanta (26-19), Houston (40-20), the Rams (45-17), Tampa Bay (20-17), and Jacksonville (27-24 OT).
The Arizona injury list matters because it hits the secondary and the front seven. Josh Sweat is questionable with an ankle issue, and Garrett Williams plus Walter Nolen III are also listed as questionable. Jalen Thompson and Max Melton are inactive, which is rough against a Bengals passing game that features Ja’Marr Chase. Budda Baker has been busy with 111 tackles, but asking any safety to clean up everything usually ends the same way.
Bengals Outlook
Cincinnati’s plan is straightforward: score early and make Arizona play catch-up. Joe Burrow has thrown for 1,268 yards with 12 touchdowns and 4 interceptions, and Ja’Marr Chase has 110 grabs for 1,256 yards. Chase Brown has carried the ground game with 846 yards on 197 rushes, so Cincinnati can stay balanced if the Bengals get a lead. The Bengals are coming off a 45-21 win over Miami, though the previous four included losses to Baltimore (24-0), Buffalo (39-34), and New England (26-20), plus a 32-14 win over Baltimore.
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Bengals vs Cardinals Prediction
Cincinnati is the pick at home because the matchup points to steady success on offense against an Arizona defense missing key players. The Bengals should also win the rushing battle when Chase Brown is gaining solid yards, which helps protect Burrow from obvious passing downs. I’m calling it Bengals 33, Cardinals 23. Make sure you know about how the fans are looking on prediction markets for the Bengals with the Thrillz promo code. Make the most of your bets on the Cardinals by using the sportsbook promos. Make sure when you place your Cardinals vs Bengals bet you are using the bet365 bonus code.
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Best Picks
- Bengals -7 (-115) is my top play based on Arizona’s skid and the injury situation in the secondary.
- Over 53.5 is also in play because Arizona games have been track meets lately, including allowing 40 and 45 in back-to-back weeks, and Cincinnati just stuck 45 on Miami. For plus money bettors, the Bengals' moneyline is too steep, so pairing Bengals -7 with the over is the better way to attack this one for NFL picks.
