Arizona Cardinals vs Indianapolis Colts Picks & Predictions for Sunday October 12, 2025

By: Thomas Pemberton Published 10/12/2025, 12:10 AM ET
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The Indianapolis Colts remain at home for Week 6 for their second straight home game. The Colts will host the Arizona Cardinals at Lucas Oil Stadium. Indianapolis is a -4 home favorite and the total is set at 46.5. The Colts beat the Cardinals 22-16 in their last meeting back in 2021. Stay up to date with our expert's Free NFL Picks. 

Arizona Cardinals Preview

The Arizona Cardinals are 1-2 on the season with a 1-1 road record. The Cardinals are 2-3 against the spread on the season. Arizona is riding a three game losing streak heading into Indianapolis. The Cardinals lost to the Tennessee Titans 22-21 in their last game at home. QB Kyler Murray threw for 220 yards and rushed for a touchdown. Murray has 6 passing touchdowns and 6 rushing touchdowns on the season. TE Trey McBride leads Arizona on the season with 29 catches. Murray is the only player with more than 19 rushing attempts.

Indianapolis Colts Preview

The Indianapolis Colts are 4-1 on the season with a perfect 3-0 home record. The Colts are 4-1 against the spread on the season. Indianapolis beat the Raiders in their last game played 40-6. QB Daniel Jones threw for 212 yards and 2 touchdowns. Jones has 6 touchdowns with 2 interceptions on the season. RB Jonathan Taylor leads the Colts with 480 rushing yards and 6 rushing touchdowns on the season. WR Michael Pittman leads the Colts with 29 catches.

Cardinals vs Colts Picks & Prediction:

The Arizona Cardinals are in jeopardy of losing their fourth straight game. Arizona's last three losses have all come by 3 points or less. The Colts have scored at least 40 points twice this season. Watch for  the Colts to be the better team on Sunday. Lay the points.

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  • Final Score Prediction: Indianapolis Colts win and cover ATS 28-20.

Cardinals vs Colts Best Free Picks:

  • Indianapolis Colts -4
  • OVER 46.5

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