Arizona Cardinals vs Seattle Seahawks Picks & Prediction for Sunday, November 9, 2025

By: Thomas Pemberton Updated 11/09/2025, 12:24 AM ET
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The Seattle Seahawks welcome the Arizona Cardinals for NFL Week 10 action. Seattle is a -6.5 home favorite and the total is set at 45.5 points. Kickoff is scheduled for 4:05 PM est at Lumen Field. Don't miss another winning play. Experience the thrill of confident decision-making with our proven methods for selecting top free NFL picks.

Arizona Cardinals Preview

The Arizona Cardinals are 4th in the NFC West with a 3-5 record. Arizona beat Dallas 27-17 on Monday Night Football in their last game. QB Jacoby Brissett threw for 261 yards and 2 touchdowns. While WR Marvin Harrison made 7 catches for 96 yards and touchdowns. Arizona  ranks 19th in the NFL averaging 22.5 points scored per game. The Cardinals head into Seattle with a 2-2 road record. Arizona is a 1-4 over their last five games played.

Seattle Seahawks Preview

The Seattle Seahawks lead the NFC West with a 6-2 record. Seattle has won four of their last five games and they are riding a three game win streak. The Seahawks beat Washington 38-14 in their last game. QB Sam Darnold threw for 330 yards with 4 touchdowns and an interception. Darnold has 16 touchdowns and 5 interceptions on the season.WR Jaxon Smith-Njigba leads Seattle with 58 catches for 948 yards and 4 touchdowns. The Seahawks are averaging 28.9 points scored per game which ranks 5th best in the NFL. Seattle is 2-2 on their home field.

Cardinals vs Seahawks Picks & Prediction

The Seattle Seahawks have covered the spread in six games this season. While the Cardinals are 5-3 against the spread. Playing in Seattle is tough for any team. Watch for the Seahawks to have the advantage in front of their home crowd. Lay the points.

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  • Final Score Prediction: Seattle Seahawks win 28-20 and cover ATS.

Cardinals vs Seahawks Best Picks

  • Seattle Seahawks -6.5
  • OVER 45.5

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