Atlanta Falcons vs. Arizona Cardinals Picks and Prediction for Sunday December 21, 2025
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On Sunday, the Atlanta Falcons (5-9) face off against the Arizona Cardinals (3-11) at State Farm Stadium in Glendale, Arizona This game will air on FOX. Keep up to date with all the NFL action, with our NFL picks.
Atlanta vs. Arizona Game Information
- December 21, 2025
- 4:05pm EST
- State Farm Stadium
- FOX
- 75° sunny/cloudy at start time
Arizona Form & Recent Results
Arizona heads into this game hoping to turn things around after dropping their last six games in a row. In their most recent outing, the Cardinals fell to Houston 40-20, despite quarterback Jacoby Brissett putting up solid numbers, he completed 27 of 40 passes for 277 yards, tossing three touchdowns along with one interception. Over the course of this season, Brissett has racked up 2,708 passing yards. Arizona has gotten contributions from running backs Bam Knight, who’s rushed for 269 yards, and Emari Demercado, who’s added 242 yards of his own. Tight end Trey McBride has emerged as a key target in the passing game, leading the team with an impressive 1,071 receiving yards so far this season. Unfortunately, the Cardinals’ defense has struggled, especially lately. Over their past five games, they’ve given up an average of 34.8 points per game, and wins have been hard to come by at home, with just one in Glendale all season. Arizona is eager to break their losing streak and is hoping to pull off a surprise victory over the Falcons in front of their home fans.
Atlanta Form & Recent Results
Atlanta comes into this matchup riding the momentum of a recent win, having edged out Tampa Bay in a nail-biting 29-28 victory. That win snapped a rough patch for the Falcons, as they had lost three of their previous five games. Quarterback Kirk Cousins was instrumental in that narrow victory, completing 30 of his 44 passes and finding the end zone three times through the air. Over the course of this season, Cousins has racked up 1,218 passing yards, a testament to his consistent play under center. Bijan Robinson continues to be a driving force for Atlanta’s offense, posting an impressive 1,174 rushing yards so far. In the receiving game, Drake London leads the wideouts with 810 yards, while tight end Kyle Pitts Jr. isn’t far behind, contributing 797 receiving yards this season. Defensively, the Falcons have faced their fair share of struggles in recent games, allowing an average of 26.4 points per game over their last five. Despite those challenges, Atlanta is hoping their big win in Tampa Bay will serve as a turning point as they hit the road once again, this time looking to carry that energy and confidence into Arizona.
Key Players
- ATL QB Kirk Cousins this season: 114/182, 6 TD, 3 INT
- ARI QB Jacoby Brissett this season: 256/386, 18 TD, 6 INT
Betting Odds & Market Overview:
- ATL -2.5; O/U 47.5
Atlanta vs. Arizona Picks and Prediction
The Cardinals have endured a rough season so far, especially in front of their home crowd, managing to win just one of their last seven games at State Farm Stadium. They'll be eager to give their fans something to cheer about and put an end to that slump when they face off against the Falcons in Glendale. On the other side, Atlanta is coming off a gritty win on the road against the Buccaneers, a hard-fought victory that could give them a much-needed boost as they prepare for this next game in Arizona. Final Score Prediction, Arizona Cardinals win 28-25. Make sure you know about how the fans are looking on prediction markets for the Falcons with the Thrillz promo code. Make the most of your bets on the Cardinals by using the sportsbook promos. Make sure when you place your Falcons vs Cardinals bet you are using the bet365 bonus code.
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