Atlanta Falcons vs. Carolina Panthers Picks and Prediction for Sunday September 21, 2025

By: Dylan Hellebrand Updated 09/19/2025, 03:15 PM ET
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On Sunday, the Atlanta Falcons (1-1) face off against the Carolina Panthers (0-2) at Bank of America Stadium in Charlotte, North Carolina. The game will be aired on FOX. Don’t miss your chance to elevate your NFL experience with free NFL picks that ignite your desire to win.

Game Information For Falcons vs Panthers

  • September 21, 2025, 1:00pm EST, Bank of America Stadium, FOX
  • 78° sunny/cloudy at start time

Carolina Panthers Form & Recent Results

The Carolina Panthers are struggling early in the season, having dropped their first two games. Last week, they fell to the Arizona Cardinals, 27-22. In that matchup, rookie quarterback Bryce Young put up solid stats, completing 35 of his 55 pass attempts for three touchdowns and one interception, bringing his season total to 482 passing yards. On the ground, running back Chuba Hubbard leads the team with 95 rushing yards across two games. In the receiving corps, Tetairoa McMillan stands out as Young's top target with 168 receiving yards, while tight end Ja’Tavion Sanders has contributed 81 yards as a reliable option. Defensively, the Panthers have struggled, giving up an average of 26.5 points through their first two games. As they try to avoid a three-game skid, it’s worth noting that last season Carolina averaged 20.1 points scored per game, so their offense will need to step up if they hope to end their losing streak.

Atlanta Falcons Form & Recent Results

The Atlanta Falcons head into this week’s matchup riding the momentum of a one-game winning streak, having split their first two games of the season. In their convincing 22-6 victory over the Minnesota Vikings last Sunday, rookie quarterback Michael Penix Jr. completed 13 of his 21 passing attempts. So far this year, Penix Jr. has racked up a total of 433 passing yards. Atlanta’s offense is also thriving thanks to running back Bijan Robinson, who has rushed for 167 yards and contributed an additional 125 yards catching the ball out of the backfield. Wide receiver Drake London has emerged as a reliable target as well, tallying 104 receiving yards through the first two weeks. With an average of 21 points scored over their first two games, the Falcons are hoping to build on the offensive momentum from their dominant performance against Minnesota. Looking back at last season, Atlanta averaged 22.9 points per game, and they appear eager to surpass that mark as they look to ignite their offense this year.

Key Players For Falcons and Panthers

  • Panthers QB Bryce Young: 53-for-90, 4 TD, 3 INT
  • Falcons QB Michael Penix Jr.: 40-for-63, 1 TD

Betting Odds & Market Overview:

  • ATL -5.5; O/U 44.5

Falcons vs Panthers Picks and Prediction 

The Falcons’ defense put on an impressive showing last week, holding the Vikings to just nine points while playing on the road. Riding the momentum from that strong performance, Atlanta’s defensive unit will aim to hand the Panthers their third consecutive defeat. Meanwhile, Carolina is still searching for their first victory of the season and will be hoping that playing in front of their home crowd provides the boost they need to finally break into the win column. Final Score Prediction, Atlanta Falcons win but fail to cover the spread, 24-23.

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