Atlanta Falcons vs San Francisco 49ers Picks and Prediction for Sunday, October 19, 2025

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Atlanta Falcons vs San Francisco 49ers Game Information

The Atlanta Falcons will again be on the road this week with a game in San Francisco inside Levi’s Stadium at 8:20 PM against the San Francisco 49ers. Atlanta comes into this game with three wins and two losses overall, riding a 2 game-winning streak after a 10-point home victory against the Buffalo Bills on Monday night. San Francisco comes into this game with four wins and two losses overall after an 11-point road loss to Tampa Bay last week. Stay in the action with our free NFL Picks.

Atlanta Falcons Preview

Offensively, Atlanta has been solid all season, averaging 20 points per game overall. Defensively, Atlanta is also allowing 20 points per game this season after giving up 14 to Buffalo in their last outing. Michael Penix Jr. leads the Atlanta offense this season with 918 yards and three touchdowns on 78 completions. Bijan Robinson is the team's top ball carrier with more than 300 yards after tying a career high Monday night. Robinson has also chipped in heavily with 270 yards and one score on 18 grabs. Drake London has been a top target with more than 300 yards this season.

San Francisco 49ers Preview

Offensively, San Francisco has been solid this season, averaging 20.8 points per game overall. Defensively, San Francisco is allowing 21.3 points per game overall, but has given up an average of 28 points per game during their two losses this season. Mac Jones leads the San Francisco offense this season with 1252 yards and six scores on 113 completions. Brock Purdy has completed 48 passes for 586 yards and four scores through two games played. Christian McCaffrey leads San Francisco with 336 yards and one touchdown on 108 carries to go along with a team-high 444 yards and three scores on 46 catches.

Atlanta Falcons vs San Francisco 49ers Game Prediction

San Francisco is likely the better team on paper, but Atlanta comes into this matchup playing their best football of the season. Look for Atlanta to play well enough on both sides of the ball to overwhelm a short-handed San Francisco team. Take the Falcons to extend their winning streak this week as they get the win and cover on the road out West. Final Score Prediction, Atlanta Falcons win and cover 27-21.

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Falcons vs 49ers Best Picks

• Atlanta Falcons ATS
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