Buffalo Bills vs Denver Broncos Picks and Prediction for Saturday January 17 2026

By: Eddie Kline Updated 01/21/2026, 02:45 PM ET

Bills Preview

The NFL Divisional Round will kickoff on Saturday afternoon, when the Buffalo Bills invade Empower Field at Mile High Stadium to take on the Denver Broncos. Get ready for all the football action with our NFL Picks. The sixth-seeded Bills (12-5) have lost in the divisional round of the playoffs in three of the previous four seasons and are in search of their first Super Bowl victory. On Sunday, Buffalo S Cole Bishop picked off Jacksonville QB Trevor Lawrence in the final minute to preserve a 27-24 road victory.

All-Pro QB Josh Allen gave Buffalo the lead with a one-yard touchdown run and finished with 273 passing yards. Allen connected with TE Daulton Kincaid on a 15-yard touchdown pass. Khalil Shakir contributed 12 receptions for a team-high 82 receiving yards. The Bills converted half of their 14 third-down attempts.

Broncos Preview

The Denver Broncos won eight of nine home games during the regular season and ended Kansas City’s nine-year run as AFC West Division Champions. The top-seeded Broncos (14-3) rank second in the league in total defense and are limiting the opposition to 18.3 points per contest. Last time out, Denver held the Los Angeles Chargers to 217 yards and forced a pair of turnovers during a 19-3 home victory.

Ja’Quan McMillian returned an interception 45 yards for Denver’s only touchdown of the afternoon. Will Lutz nailed field goals of 24, 26, 41, and 23 yards. QB Bo Nix rushed for a team-high 45 yards and LB Nik Bonitto added 1.5 sacks for the Broncos.

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Bills vs Broncos Pick

Buffalo TE Daulton Kincaid was wearing a walking boot after Sunday’s victory and is listed as questionable for this game. These two teams rank in the top seven of the NFL in total defense, so the under is worth a look. The stronger play is on Josh Allen to lead the Bills to a road victory. Final Score Prediction, Buffalo Bills win 24-19.

How To Bet This Matchup

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