Buffalo Bills vs Houston Texans Picks and Prediction for Thursday November 20 2025

By: Eddie Kline Published 11/18/2025, 12:03 AM ET

Bills Preview

The week 12 NFL schedule will kick off on Thursday night with a battle between the Buffalo Bills and the Houston Texans from NRG Stadium. Get ready for all the football action with our NFL Picks. The Bills (7-3) have split their first four road games and trail New England by 1.5 games for first place in the AFC East Division. On Sunday, Buffalo outscored Tampa Bay by 11 points in the second half to pull away for a 44-32 home victory.

All-Pro QB Josh Allen completed 19 of 30 passes for 317 yards and three touchdowns. Buffalo WR Tyrell Shavers caught four passes for 90 yards and a score. S Jordan Poyer recorded 15 tackles (7 solo) for the Bills, who overcame three turnovers on the afternoon. Make sure you know about how the fans are looking on prediction markets for the Bills with the Thrillz promo code.

Texans Preview

The Houston Texans are a game above .500 at home and own a plus 57 point differential overall. The Texans (5-5) lead the league in total defense and are limiting the opposition to 16.3 points per contest. Last week, Matthew Wright nailed a 35-yard field goal as time expired to lift Houston to a 16-13 road victory against Tennessee.

Houston QB Davis Mills made his second consecutive start in place of C.J. Stroud and threw for 274 yards. Mills hit Nico Collins on a three-yard touchdown pass to give the Texans a 7-6 lead midway through the third quarter. Houston held Tennessee to 229 yards and forced the only turnover of the game. Make the most of your bets on the Texans by using the sportsbook promos.

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Bills vs Texans Pick

Buffalo TE Dalton Kincaid missed Sunday’s victory with a hamstring injury and is listed as questionable for this contest. The Bills rank in the middle of the NFL in total defense and are giving up 22.9 points per game. Look for Buffalo to win on the road in a game that goes over the total. Final Score Prediction, Buffalo Bills win 27-22. Make sure when you place your Bills vs Texans bet you are using the bet365 bonus code.

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