Carolina Panthers vs Arizona Cardinals Picks and Predictions for Sunday, September 14, 2025

By: Jake Allman Published 09/08/2025, 09:23 PM ET

Panthers vs Cardinals Game Preview

The Panthers head West to face the Cardinals at State Farm Stadium in Glendale, with kickoff scheduled for 2:05 PM ET on CBS. Arizona is favored by -4.5 at home, with the total set at 45.5 points. The Cardinals come in 1-0 after a road win, while Carolina is looking to avoid a 0-2 start. From underdogs to point spreads, we’ve got the sharpest nfl picks.

Panthers Preview

Carolina struggled in its opener, falling 26-10 at Jacksonville. Bryce Young completed 18 of 35 passes for 154 yards with one touchdown and two interceptions. Chuba Hubbard was a bright spot on the ground, rushing for 57 yards on 16 carries, but the offense lacked explosive plays and failed to sustain drives. Tetairoa McMillan led the receiving group with 68 yards, though turnovers and inefficiency limited scoring chances. Defensively, Baron Browning recorded a sack, while safety Tre’von Moehrig led the team with 11 tackles.

The Panthers’ biggest issue continues to be offensive consistency. Young is still searching for rhythm, and the line has had trouble keeping him comfortable in the pocket. Injuries also add concern, with Patrick Jones II and Tershawn Wharton questionable, while starting tackle Ikem Ekwonu is inactive. Without stability up front, the offense will need Hubbard to grind out yardage and take pressure off the passing attack.

Cardinals Preview

Arizona started its season with a 20-13 win in New Orleans behind a balanced effort. Kyler Murray looked sharp, completing 21 of 29 passes for 163 yards and two touchdowns. Rookie back Trey Benson provided 69 rushing yards on just eight carries, showing explosive ability. Marvin Harrison Jr. highlighted the passing attack with 71 yards and a touchdown, instantly proving to be a difference-maker. Safety Budda Baker anchored the defense with 10 tackles, while the unit forced stops in key moments to preserve the win.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

The Cardinals have plenty of optimism after Week 1, particularly with Murray’s command of the offense and Benson’s burst in the run game. If Harrison continues emerging as a go-to weapon, Arizona’s passing attack will stretch defenses in ways it couldn’t last year. Defensively, the health of Zaven Collins and Joey Blount is worth watching, but the group has the speed to cause problems for Carolina’s offensive line.

Cardinals vs Panthers Free NFL Pick

This matchup tilts toward the Cardinals thanks to offensive balance and home-field advantage. Carolina’s offense looks one-dimensional and prone to mistakes, while Arizona has playmakers at every level. If Murray maintains his strong play, the Panthers will have a hard time keeping pace on the road.

Prediction: Arizona Cardinals 27, Carolina Panthers 16

Betting on the NFL?

Be sure to look our our list of the best NFL online sportsbooks
Grow your bankroll by claiming one of our favorite NFL sportsbook promo codes

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.