Carolina Panthers vs San Francisco 49ers Picks and Prediction for Monday November 24 2025

By: Eddie Kline Published 11/18/2025, 12:04 AM ET

Panthers Preview

Beautiful Levi’s Stadium will play host to a Monday night NFL clash between the Carolina Panthers and the San Francisco 49ers. Get ready for all the football action with our NFL Picks. The Panthers (6-5) have split their first six road games and trail Tampa Bay by a half-game for the top spot in the NFC South Division. On Sunday, Ryan Fitzgerald’s 28-yard field goal in overtime sent Carolina to a 30-27 road victory against Atlanta.

Carolina QB Bryce Young threw for a franchise record 448 yards and three touchdowns. Rookie WR Tetairoa McMillan torched the Atlanta secondary for 130 receiving yards and two scores. Xavier Leggette added 83 receiving yards and a touchdown for the Panthers. Make sure you know about how the fans are looking on prediction markets for the Panthers with the Thrillz promo code.

49ers Preview

The San Francisco 49ers are 4-1 in NFC West Division play and are 1.5 games back of Los Angeles for first place. The 49ers (7-4) rank second in the league in passing offense and are scoring 23.7 points per contest. Last week, San Francisco built a 15-point halftime advantage and forced three turnovers during a 41-22 road triumph against Arizona.

San Francisco Brock Purdy returned to action from a toe injury to throw for 200 yards and two touchdowns. All-Pro RB Christian McCaffrey contributed a game-high 81 rushing yards and a score for the 49ers, who won despite being outgained by a 488-281 margin. Make the most of your bets on the 49ers by using the sportsbook promos.

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Panthers vs 49ers Pick

San Francisco WR Brandon Aiyuk (knee) will not resume practicing this week and will remain sidelined for this game. The Panthers are playing their third road game in four weeks and that will finally catch up to them. The 49ers are starting to get healthy and that is a dangerous proposition for the rest of the NFL. Take San Francisco to cover at home. Final Score Prediction, San Francisco 49ers win 30-17. Make sure when you place your Panthers vs 49ers bet you are using the bet365 bonus code.

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