Detroit Lions vs Arizona Cardinals Picks and Predictions for Sunday October 11 2026
The Detroit Lions visit the Arizona Cardinals at State Farm Stadium in Glendale, Arizona, on Sunday, October 11, 2026. Kickoff is scheduled for 4:25 PM ET. Detroit enters at 2-2 after losing 32-26 at Carolina, while Arizona is 1-3 following a 36-24 loss to the New York Giants. Both defenses struggled last week, creating one of Sunday’s more interesting potential shootouts. Be sure to check out our free NFL picks for more NFL predictions throughout the season.
Detroit Needs Its Defense to Catch Up
Detroit scored 26 points at Carolina and still left with a loss. That’s the frustrating part of the Lions’ 2-2 start: the offense has shown enough ability to win games, but the defense hasn’t consistently provided the support required.
The good news is that Arizona presents another favorable offensive matchup. The Cardinals just surrendered 36 points to New York, giving Detroit an opportunity to immediately get back into rhythm.
The Lions should be able to move the football. Whether they cover depends on getting enough defensive stops to prevent Arizona from hanging around into the fourth quarter.
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Arizona Has the Same Problem
The Cardinals’ 36-24 loss to the Giants looked remarkably similar from a betting perspective. Arizona scored enough to remain competitive offensively but couldn’t get the defensive stops necessary to threaten the win.
That creates an intriguing matchup against Detroit. Both teams enter knowing they can generate points, and neither defense comes into Sunday with much reason for confidence.
Home field gives Arizona some value as an underdog, but the Cardinals need to show they can slow a capable offense before I’m ready to take the points.
Detroit Lions vs Arizona Cardinals Picks and Predictions
Pick: Detroit Lions ATS
Detroit is the side pick. The Lions’ loss at Carolina was disappointing, but Arizona’s defensive performance against New York was even more concerning. Detroit scored 26 despite losing and should find plenty of opportunities against a Cardinals defense that just surrendered 36. I’m willing to back the Lions to rebound, particularly if the spread remains within a manageable one-possession range.
Pick: Over
The Over is my favorite angle in this matchup. Detroit’s Week 5 game produced 58 combined points, while Arizona’s produced 60. Both teams scored at least 24 and both defenses surrendered at least 32. There isn’t much reason to expect either side to completely change its profile in one week. Detroit should get into the upper 20s again, and Arizona has enough offense at home to contribute.
Final Picks: Detroit Lions ATS and Over
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