Detroit Lions vs Baltimore Ravens Picks and Prediction for Monday September 22 2025

By: Eddie Kline Updated 09/19/2025, 03:11 PM ET

Lions Preview

M&T Bank Stadium will play host to a Monday night NFL clash between the Detroit Lions and the Baltimore Ravens. Tap into the psychology of success this NFL season with expert strategies that lead to winning free NFL picks. The Lions (1-1) reached the NFC Conference Championship two years ago and are looking to make their first Super Bowl appearance in franchise history. On Sunday, Detroit scored 10 plus points in each quarter and averaged 8.8 yards per play during a 52-21 home victory versus Detroit.

Detroit QB Jared Goff shredded the Chicago secondary for 334 passing yards and five touchdowns. Amon-Ra St. Brown was on the receiving end of three of the scores and finished with a team-high 115 receiving yards. Jahmyr Gibbs contributed 94 rushing yards and a score for the Lions, who rolled up 511 yards of total offense.

Ravens Preview

The Baltimore Ravens have been one of the most successful regular season teams, but are looking to advance to the AFC Championship for the first time in more than a decade. The Ravens (1-1) rank fifth in the league in rushing offense and lead the NFL in scoring at 40.5 points per game. Last week, Baltimore erupted for 31 points during the second half of a 41-17 home victory versus Cleveland.

Two-time NFL MVP Lamar Jackson completed 19 of 29 passes for 225 yards and four touchdowns. LB Roquan Smith returned a fumble 63 yards for a score to give Baltimore a commanding 34-10 lead. Zay Flowers added a game-high 75 receiving yards on seven receptions for the Ravens.

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Lions vs Ravens Pick

Baltimore LB Kyle Van Noy suffered a hamstring injury during Sunday’s victory and is expected to miss several weeks. These are two of the top three scoring teams in the league, so the over is worth a look. The stronger play is to take the points with the Lions. Final Score Prediction, Baltimore Ravens win 28-27.

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