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Detroit Lions vs Los Angeles Rams Picks and Predictions for Saturday, December 13, 2025

By: Cameron Ross Published 12/13/2025, 10:49 PM ET

Detroit Lions vs Los Angeles Rams Game Information

The Detroit Lions end a 2-game homestand Sunday afternoon with a game in Los Angeles against the Los Angeles Rams. Detroit has eight wins and five losses this season, coming into this week having won three of the last five after a 14-point home win against the Dallas Cowboys. The Los Angeles Rams return home this week with ten wins and three losses after winning 4 of the last five following a 28-point road victory against the Arizona Cardinals last week. Stay in the action with our NFL Picks.

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Detroit Lions Preview

Jared Goff leads the Detroit offense this season with 3334 yards and 26 touchdowns on 289 completions. Jahmyr Gibbs is the top ball carrier on the Detroit roster with 1062 yards and 13 scores on 187 carries, while David Montgomery has added 129 carries for 603 yards and seven touchdowns. Amon-Ra St. Brown leads all Detroit receivers on the team with 976 yards and nine touchdowns on 81 receptions.

Los Angeles Rams Preview

Matthew Stafford leads the Los Angeles offense this season with 3354 yards and 35 touchdowns on 288 completions. Kyren Williams is the top running back on the roster with 952 yards and eight touchdowns on 196 carries. Puka Nacua leads the Los Angeles offense this season with 1186 yards and six touchdowns on 93 receptions. Davante Adams has added 718 yards and 13 scores on 56 catches this year.

Detroit Lions vs Los Angeles Rams Prediction

Los Angeles is the better team in this matchup, playing great football coming into this week. Look for Los Angeles to keep rolling against a mediocre Detroit team at home. Take the Rams to continue their winning ways as they pick up the win and cover Sunday afternoon against Detroit. Final Score Prediction, Los Angeles Rams win and cover 41-27. Make sure you know about how the fans are looking on prediction markets for the Lions with the Fliff promo code. The best sportsbooks are the best way to go when you are betting on the Rams. Make sure when you place your Lions vs Rams bet you are using the bet365 bonus code.

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Lions vs Rams Best Picks

  • Los Angeles Rams -6
  • Over 54.5
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