Indianapolis Colts vs Kansas City Chiefs Picks and Predictions for Sunday, November 23, 2025
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The Indianapolis Colts face the Kansas City Chiefs on Sunday afternoon at GEHA Field at Arrowhead Stadium. Indianapolis is 8–2 overall and 2–2 on the road after a 31–25 overtime win against Atlanta, winning four of its last five. Kansas City is 5–5 overall and 4–1 at home after a 22–19 loss at Denver, dropping its second straight. Kick the winning field goal and cash in with NFL picks.
Colts vs Chiefs Game Information
- Date: Sunday, November 23
- Time: 1:00 PM ET
- Where: GEHA Field at Arrowhead Stadium, Kansas City, Missouri
- TV: CBS
Indianapolis Colts Preview
Quarterback Daniel Jones has completed 69.9% of his passes for 2,659 yards with 15 touchdowns and seven interceptions, averaging 265.9 passing yards per game. Jonathan Taylor is having a huge year on the ground with 1,139 rushing yards and 15 touchdowns on 189 carries, averaging 113.9 yards per game at 6.0 yards per rush. Tight end Tyler Warren leads the Colts with 50 receptions for 617 yards and three scores.
Safety Nick Cross leads the defense with 69 tackles, and pass rusher Laiatu Latu has five sacks, backed by DeForest Buckner and Kwity Paye up front. Indianapolis has won four of its last five, topping 30 points in three of those victories, and the kicking game has been strong with Spencer Shrader and Michael Badgley combining to hit 20 of 22 field goals. The best sportsbooks are the best way to go when you are betting on the Colts.
Kansas City Chiefs Preview
Patrick Mahomes has completed 64.5% of his passes for 2,625 yards with 18 touchdowns and six interceptions, averaging 262.5 yards per game. The run game is spread around, with Kareem Hunt posting 353 rushing yards and six touchdowns and Isiah Pacheco adding 329 yards and a score. Travis Kelce leads the Chiefs in receiving with 50 catches for 631 yards and four touchdowns, while Hollywood Brown has 429 yards and four scores.
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Defensively, linebacker Nick Bolton leads Kansas City with 81 tackles, and George Karlaftis has five sacks, supported by Chris Jones and Mike Danna on the line. The Chiefs have allowed 22 points or fewer in four of the last five. Harrison Butker is the kicking game for the Chiefs, converting 16 of 19 field goals, including multiple makes from 50-plus yards. Make sure you know about how the fans are looking on prediction markets for the Chiefs with the Onyx Odds promo code.
Indianapolis Colts vs Kansas City Chiefs Prediction
Indianapolis comes in with the better record and a more explosive ground attack behind Taylor, but Arrowhead is tough on visiting teams. Mahomes and Kelce still lead one of the league’s more dangerous passing attacks, and Kansas City has been much better at home than on the road. Expect a competitive game with Mahomes making late throws to win it. Final Score Prediction: Kansas City Chiefs win and cover ATS, 28–23. Getting the most out of your bets on Colts vs Chiefs can be done by using the Fanatics Sportsbook promo code.
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Best Picks
- Kansas City Chiefs -3.5
- Over 49.5
- Jonathan Taylor Anytime Touchdown
