Indianapolis Colts vs Washington Commanders Picks and Predictions for Sunday October 4 2026
The Indianapolis Colts face the Washington Commanders at Tottenham Hotspur Stadium in London, England, on Sunday, October 4, 2026. Kickoff is scheduled for 9:30 AM ET. Both teams enter at 1-2 after earning their first victories of the season in Week 3. Indianapolis defeated Houston 19-17, while Washington upset Seattle 33-31. The Colts are currently 3-point favorites, with Indianapolis around -162 on the moneyline, Washington around +148, and the total sitting at 47 to 47.5. Be sure to check out our free NFL picks for more NFL predictions throughout the season.
Colts Head Overseas After First Victory
Indianapolis finally broke through last week with a 19-17 victory over Houston. The Colts had opened the year with losses to Baltimore and Kansas City, so getting into the win column before traveling to London was particularly important.
The 19-point offensive performance wasn’t overwhelming, but Indianapolis showed enough balance to survive a close game. The Colts now face a Washington defense that has struggled to consistently prevent opponents from moving the football, creating an opportunity for Indianapolis to produce its most complete offensive showing of the young season.
The Colts also enter as the favorite despite playing at a neutral site. Indianapolis will need to avoid allowing Washington’s defense to create short fields because the Commanders showed last week that they can capitalize when a game becomes high scoring.
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Commanders Coming Off Dramatic Win
Washington also improved to 1-2 by defeating Seattle 33-31. That performance was considerably more encouraging offensively than what the Commanders had produced during their first two games.
The biggest concern heading to London is quarterback availability. Washington enters the week with uncertainty at the position, and that matters significantly against an Indianapolis team that has enough offensive capability to force the Commanders to score into the 20s.
Washington showed against Seattle that it can win a close game, but repeating that performance overseas becomes a difficult assignment. The Commanders need another efficient offensive effort while finding a way to generate more defensive stops than they did against Seattle.
Indianapolis Colts vs Washington Commanders Picks and Prediction
Pick: Indianapolis Colts -3
Indianapolis is the preferred side at a field goal. Both clubs are 1-2, but Washington’s quarterback situation creates additional uncertainty entering an international game. The Colts have already faced Baltimore and Kansas City before defeating Houston, giving Indianapolis a fairly demanding opening schedule. Washington’s defense allowed 31 points last week, and Indianapolis should find enough scoring opportunities to create separation. At exactly -3, I’ll lay the field goal with the Colts.
Pick: Over 47
Washington’s 33-31 win over Seattle produced 64 points and demonstrated how quickly a Commanders game can open up when their opponent finds offensive success. Indianapolis scored only 19 last week, but this is a more favorable defensive matchup. Washington should also contribute enough offense to keep the Colts aggressive. A final score around 27-23 or 28-24 gets this game above the number.
Final Picks: Indianapolis Colts -3 and Over 47
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