Kansas City Chiefs vs New York Giants Picks and Predictions for Sunday, September 21, 2025

By: Cameron Ross Updated 09/19/2025, 03:11 PM ET
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Chiefs vs Giants Game Information

The Kansas City Chiefs will take their first road trip of the season this week with a game in East Rutherford against the New York Giants at MetLife Stadium at 8:20 PM. Kansas City is winless this season following a narrow 3-point loss to Philadelphia a week ago. The New York Giants will be at home this week for the first game of the season against Kansas City. The New York Giants returned home this week, winless through two games played after a three-point overtime loss on the road to Dallas a week ago. Experience the thrill of confident decision-making with our proven methods for selecting top free NFL picks.

Kansas City Chiefs Preview

Offensively, Kansas City scored the ball well this season, averaging 19 points per game through two games played. Defensively, Kansas City has been horrendous, allowing 23.5 points per game overall. Patrick Mahomes leads the Kansas City offense this season with 445 yards and two scores on 40 completions to go along with 123 yards and two touchdowns on 13 carries this year. Hollywood Brown is the top receiver for Kansas City this season with 129 yards on 15 receptions.

New York Giants Preview

Offensively, New York has been mediocre this season, averaging 21.5 points per game overall, but scored only 6 points in their season opener. Defensively, New York has been terrible, allowing 30.5 points per game after giving up 40 to Dallas a week ago. Russell Wilson leads the New York offense this season with 618 yards and three scores on 47 completions, along with a team high 67 yards on 11 carries. Malik Nabers is the top receiver on the roster with 238 yards and two scores on 14 grabs.

Chiefs vs Giants Game Prediction

The Kansas City Chiefs desperately need to get their season on track and will do so this week. Both teams are winless this year, but Kansas City remains one of the best teams in the league. Take Kansas City to dominate this game on both sides of the ball as they overwhelm New York for 60 minutes, leading to a win and cover on the road in New York. Final Score Prediction, Kansas City Chiefs win and cover 34-17.

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Chiefs vs Giants Best Picks    

  • Kansas City Chiefs -6.5
  • Over 44.5

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