Las Vegas Raiders at Indianapolis Colts Picks and Predictions for Sunday, October 5, 2025

By: David Anicetti Updated 10/03/2025, 10:43 PM ET

The Las Vegas Raiders visit the Indianapolis Colts on Sunday at Lucas Oil Stadium with the opening kickoff at 1:00 p.m. ET on FOX. Las Vegas is 1–3 after a 25–24 loss to Chicago and is T-3rd in the AFC West. Indianapolis is 3–1 after a 27–20 loss at the Rams and is T-1st in the AFC South. Stay ahead of the game by using our free NFL picks that harness emotional insights to drive results.

Las Vegas Raiders Preview

The Raiders have struggled to finish drives through four games. Geno Smith has 948 yards, 6 touchdowns, and 7 interceptions on 63.8% passing. Jakobi Meyers leads all receivers with 258 yards on 21 catches, while Brock Bowers has 225 yards, and Tre Tucker has 224 yards and 4 scores. On the ground, Ashton Jeanty has 282 yards and 2 touchdowns, but the run has not been used often as the Raiders play catch-up due to trailing most of the time.

Michael Mayer is out with a concussion. The Raiders have allowed 12 sacks, and turnovers have stalled scoring chances. On defense, Devin White leads with 34 tackles, Maxx Crosby has an interception, and Jonah Laulu has 3.0 sacks. The Raiders have let opponents score 20 or more points in three straight games.

Indianapolis Colts Preview

Daniel Jones has been solid under center, completing 71.9% of his passes for 1,078 yards with 4 touchdowns and 2 interceptions. Jonathan Taylor has 414 yards and 3 touchdowns on 77 carries, giving the Colts a steady ground game. Michael Pittman Jr. has 234 yards and 3 touchdowns, while Tyler Warren leads the team with 263 receiving yards.

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The Colts’ defense has been steady. Nick Cross leads with 34 tackles, and Cam Bynum has 2 interceptions. The pass rush is spread across several players, helping to stall drives for opponents with sacks and QB pressures. Kicker Spencer Shrader is 13-of-14 on field goals and has not missed an extra point, giving Indianapolis a strong kicking game.

Las Vegas Raiders vs Indianapolis Colts Prediction

The Colts have the more reliable quarterback, a stronger running game, and a defense that makes more stops. Las Vegas has weapons, but turnovers and problems protecting the passer make it tough to have sustained drives. At home, Indianapolis will control the game from start to finish. Final Score Prediction: Indianapolis Colts win and cover ATS 30-20.