Los Angeles Chargers vs Las Vegas Raiders Picks and Prediction for Monday September 15 2025

By: Eddie Kline Updated 09/15/2025, 10:40 AM ET

Chargers Preview

Beautiful Allegiant Stadium will play host to a Monday night NFL clash between the Los Angeles Chargers and the Las Vegas Raiders. Get ready for all the football action with our NFL Picks. The Chargers (1-0) are coming off an 11-win season and allowed just 17.7 points per game for head coach Jim Harbaugh. In their season opener, Los Angeles raced out to a ten-point advantage and held on for a 27-21 victory versus Kansas City in Brazil.

Los Angeles QB Justin Herbert outdueled Patrick Mahomes with 318 passing yards and three touchdowns. WR Quentin Johnson hauled in five passes for a team-high 79 yards and scored twice. Rookie RB Omarion Hampton added 48 rushing yards for the Chargers, who converted 7 of 13 third-down attempts.

Raiders Preview

Since relocating to Las Vegas, the Raiders have reached the postseason just once and have compiled a 37-48 overall record. The Raiders (1-0) ranked near the bottom of the league in total offense last season and hired veteran head coach Pete Carroll to turn things around. On Sunday, Las Vegas limited New England to three points during the second half to earn a 20-13 road victory.

Las Vegas QB Geno Smith was stellar in his team debut with 362 passing yards and a 26-yard touchdown pass to Tre Tucker. Rookie RB Ashton Jeanty contributed 38 rushing yards and a three-yard score. TE Brock Bowers added 103 receiving yards for the Raiders, who outgained the Patriots by a 389-336 margin.

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Chargers vs Raiders Free Pick

Las Vegas TE Brock Bowers was forced to exit Sunday’s victory with a knee injury and is listed as questionable for this game. Despite being on the road, Los Angeles should have plenty of fan support. Look for Herbert to have another stellar day and lead the Chargers to a road victory and cover.

Chargers vs Raiders Score Prediction

Final Score Prediction, Los Angeles Chargers win 27-19.

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