Los Angeles Chargers vs New York Giants Picks and Prediction for Sunday September 28 2025

By: Thomas Pemberton Updated 09/26/2025, 01:07 PM ET
Use Code PPWC

The New York Giants will host their second straight home game in Week 4 when they host the Lost Angeles Chargers. The Giants are still seeking their first win of the season. While the LA Chargers are hoping to remain undefeated. The Chargers are a -6.5 road favorite and the over/under is set at 44 points. Don’t miss your chance to elevate your NFL experience with free NFL picks that ignite your desire to win.

New York Giants Preview

The New York Giants limp into Week 4 with a 0-3 record. The Giants are 0-1 at MetLife Stadium. New York lost to the Chiefs in their home opener last week 22-9. The Giants were shutout in two quarters in that game and allowed points in all four quarters. QB Russell Wilson threw for 160 yards in the loss with no touchdowns and 2 interceptions. Wilson has 3 passing touchdowns on the season with 3 interceptions. WR Malik Nabers has been Wilson's top target. Nabers has 16 catches on the season and 2 touchdowns.

Los Angeles Chargers Preview

The Los Angeles Chargers are feeling good as they roll into Week 4 of action. The Chargers are 3-0 on the season with a 1-0 road record. The Chargers have scored at least 20 points in all three games this season. Los Angeles beat Denver at home last week 23-20. QB Justin Herbert threw for 300 yards in the win with a touchdown and an interception. Herbert has 6 passing touchdowns on the season with 1 interception. Veteran receiver Keenan Allen leads the Chargers with 19 catches on the season. Allen has 194 receiving yards and 3 touchdowns.

Chargers vs Giants Free Picks & Predictions

The New York Giants are a tough team to get behind this season as they look just awful. The Giants are 1-2 against the spread. While the Chargers are 2-0-1 against the spread. The Chargers beat the Giants 37-21 in their last meeting back in 2021. Lay the points with the better team as the Chargers offense will be too much for the Giants to keep pace with.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Betting on the NFL?

BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $200 in Bonuses Instantly!

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Odds Requirements -500
Cashable No
Video: World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
World Cup: Mexico vs England BEST Bets & Predictions | July 5, 2026
Video: Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026
Brazil vs Norway: The Bet You AREN'T Thinking Of! | BEST World Cup Predictions | July 5, 2026
  • Final Score Prediction: Los Angeles Chargers win 31-16 and cover ATS.

Chargers vs Giants Free NFL Picks:

  • Los Angeles Chargers -6.5
  • OVER 44
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.