Los Angeles Chargers vs Seattle Seahawks Picks and Predictions for Sunday October 4 2026

By: Kim Smith Published 09/29/2026, 10:36 PM ET

The Los Angeles Chargers visit the Seattle Seahawks at Lumen Field in Seattle, Washington, on Sunday, October 4, 2026. Kickoff is scheduled for 4:25 PM ET with coverage on CBS. Los Angeles is 0-3 after losing 24-16 to Buffalo, while Seattle is 2-1 following a surprising 33-31 loss to Washington. FanDuel currently has Seattle as a 7-point home favorite, with the Seahawks at -350 on the moneyline, Los Angeles at +280, and the total set at 43.5. Be sure to check out our free NFL picks for more NFL predictions throughout the season.

Chargers Still Searching for First Win

Los Angeles remains winless after three games, dropping to 0-3 with last week’s 24-16 defeat at Buffalo. The Chargers have scored only 44 points through three games, putting enormous pressure on the defense to keep every game within reach.

The offense has struggled on third down and has been one of the league’s least efficient units overall. That becomes especially concerning against a Seattle defense that has been excellent against the pass through the opening weeks.

Los Angeles did create turnovers against Buffalo, but even winning that battle wasn’t enough. The Chargers now need a substantially cleaner offensive performance in one of the league’s more difficult road environments.

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Seahawks Look to Bounce Back

Seattle suffered its first loss in dramatic fashion last week, falling 33-31 to Washington as a heavy favorite. The defeat was surprising, but it doesn’t erase the strength of a defense that had been dominant through the first two games.

The Seahawks have allowed very little through the air and now face a Chargers offense that has struggled to create efficient passing production. That is a strong matchup advantage for Seattle.

The primary concern is laying a full touchdown following a defensive letdown. Still, the Chargers’ offensive struggles make it difficult to trust Los Angeles to consistently punish Seattle even if the Seahawks aren’t at their best.

Los Angeles Chargers vs Seattle Seahawks Picks and Prediction

Pick: Seattle Seahawks -7

Seattle laying a full touchdown is aggressive, but the matchup strongly favors the home team. Los Angeles is 0-3 and ranks near the bottom of the league in offensive efficiency, while Seattle’s pass defense has been among the NFL’s best. The Seahawks should also be highly motivated after last week’s upset loss. If Seattle avoids turnovers, it should have enough control to win by at least seven.

Pick: Under 43.5

The Chargers have scored only 44 points through three games, and Seattle’s defense is well suited to limit their passing game. The Seahawks don’t need to play aggressively if they gain an early lead and can lean on their defense and field position. Los Angeles may struggle to reach 20 points, making a score around 24-16 or 27-13 realistic. Take the Under.

Final Picks: Seattle Seahawks -7 and Under 43.5

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