Los Angeles Rams vs Tennessee Titans Picks and Predictions for Sunday, September 14, 2025
The Los Angeles Rams travel to Nissan Stadium on Sunday to play the Tennessee Titans, kicking off at 1:00 PM ET on CBS. Los Angeles opened the season with a 14-9 win over Houston, while the Titans fell 20-12 in Denver. The market favors Los Angeles at -5.5 with a total set at 41.5. Join us here for our NFL picks.
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Los Angeles Rams Preview
Matthew Stafford looked sharp in the opener, completing 72% of his passes for 245 yards and a touchdown while spreading the ball effectively. Puka Nacua dominated with 10 receptions for 130 yards. Kyren Williams balanced the offense with 66 rushing yards and a touchdown on 18 carries, giving the Rams. The offensive line did surrender three sacks, but Stafford’s quick release minimized overall damage and helped to keep drives alive.
The Rams’ defense allowed just nine points to Houston. Kam Curl led with 10 tackles, while Cobie Durant grabbed an interception to seal the game late. The front, anchored by Jeffery Simmons, produced three sacks and closed down Houston’s red-zone chances. If Los Angeles continues to create pressure while controlling possession with Williams, the team can dictate tempo against Tennessee’s offense.
Tennessee Titans Preview
Tennessee struggled in Denver, with quarterback Cam Ward limited to 112 passing yards on 12-of-28 attempts. The Titans’ offensive line allowed six sacks, stalling drives, and forcing early punts. Tony Pollard was the lone bright spot, running 18 times for 60 yards while also leading in receiving with 29 yards. Calvin Ridley managed 27 yards on four catches, but the passing game lacked rhythm. Improving protection and sustaining drives are priorities to keep the defense from wearing down.
On defense, Tennessee had some solid performances with Jeffery Simmons registering a sack and Cody Barton pacing the team with nine tackles. Xavier Woods added an interception, but Denver’s balanced attack controlled possession and limited big-play opportunities for the Titans’ secondary. The special teams performed, as Joey Slye nailed all four field goals, including a long of 50, proving reliable when drives stalled.
Los Angeles Rams vs Tennessee Titans Prediction
Los Angeles had better quarterback play in Week 1, has more explosive threats on the ground and through the air, and is steadier on the offensive line. Tennessee’s inability to protect Ward against Denver raises major concerns about a Rams defense that thrives on pressure. Final Score Prediction: Los Angeles Rams win and cover ATS 24-13
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +2,576.00 |
| 2 |  Ross Benjamin | +1,654.00 |
| 3 |  Earle Sports Bets | +1,541.00 |
| 4 |  Dan Kaiser | +1,397.00 |
| 5 |  Mark Ruelle | +784.00 |
Best Picks:
- Los Angeles Rams -5.5
- Under 41.5.
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