Minnesota Vikings vs Los Angeles Chargers Picks and Prediction for Thursday October 23 2025

By: Eddie Kline Published 10/20/2025, 10:38 PM ET

Vikings Preview

The week eight NFL schedule will kick off on Thursday night with a battle between the Minnesota Vikings and the Los Angeles Chargers from beautiful SoFi Stadium. Get ready for all the football action with our NFL Picks. The Vikings (3-3) rank eighth in the league in total defense and are allowing 20.8 points per game. On Sunday, Minnesota was unable to overcome a second quarter pick-six during a 28-22 home loss versus Philadelphia.

Minnesota QB Carson Wentz was under siege all afternoon from a fierce Philadelphia pass rush and finished with 313 passing yards. Jordan Mason carried 15 times for 57 yards and a score. Will Reichard booted five field goals, including a 59-yard bomb to get the Vikings on the scoreboard.

Chargers Preview

The Los Angeles Chargers are undefeated through three AFC West Division games and are a game behind Denver for first place. The Chargers (4-3) rank fourth in the league in total offense and are scoring 21.6 points per contest. Last week, Los Angeles was outscored by 17 points during the second quarter of a 38-24 home loss versus Indianapolis.

All-Pro QB Justin Herbert tried his best to rally Los Angeles with a season-high 420 passing yards and three touchdowns. Rookie TE Orande Gadsden II caught seven passes for 164 yards and a score. The Chargers committed a pair of turnovers and allowed 5.2 yards per rush to the Colts.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Vikings vs Chargers Pick

Minnesota QB J.J. McCarthy (ankle) was inactive as the team’s emergency quarterback on Sunday. Los Angeles played last week without injured LT Joe Alt (ankle) and rookie RB Omarion Hampton (ankle). The Chargers are too banged up on the offensive line to be favored in this spot. Take the Vikings to win on the road. Final Score Prediction, Minnesota Vikings with 24-20.

Betting on the NFL?

Be sure to look our our list of the best NFL online sportsbooks
Grow your bankroll by claiming one of our favorite NFL sportsbook promo codes

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.