New England Patriots vs Buffalo Bills Picks and Predictions for Sunday, October 5th, 2025

By: Cameron Ross Updated 10/03/2025, 10:41 PM ET

New England Patriots vs Buffalo Bills Game Information

The New England Patriots take a short road trip this week to Highmark Stadium for a matchup on prime time against the Buffalo Bills at 8:20 PM. New England has split their first two games of the season coming into this week, following a blowout 29-point victory against Carolina a week ago. The Buffalo Bills have already emerged as one of the best teams in the AFC, undefeated through four games played this season, following a 12-point victory against New Orleans last week. Experience the thrill of confident decision-making with our proven methods for selecting top free NFL picks.

New England Patriots Preview

The New England Patriots have been mediocre on the offensive side of the ball this season, averaging 27.25 points per game overall. Defensively, New England has been better this season, allowing 20.25 points per game through four games played. Drake Maye leads the New England offense this season with 908 yards and seven scores on 91 completions. Rhamondre Stevenson is the top ball carrier for the Patriots with 125 yards on 31 carries. Stefon Diggs has fit in well with his new team this season, leading the way with 213 yards on 19 receptions. Hunter Henry has chipped in 15 catches for 204 yards and three scores this year.

Buffalo Bills Preview

Offensively, Buffalo is rolling to start the year, averaging 33.25 points per game overall. Defensively, Buffalo is just as strong, holding opponents to just 22.5 points per game through the first four games of the season. Josh Allen leads the Buffalo offense this season with 964 yards and seven scores on 85 completions. James Cook has boasted a team-high 401 yards and five scores on 75 carries. Keon Cook leads the team with 203 yards and one touchdown on 17 catches. Khalil Shakir has chipped in 16 catches for 190 yards and two touchdowns.

New England Patriots vs Buffalo Bills Game Prediction

New England has started the year mediocre and will struggle against the potent Buffalo offense. Look for Buffalo to grab an early lead, leading to an easy victory on Sunday. Take the Bills to stay undefeated this week as they get the win and cover at home against a divisional foe. Final Score Prediction, Buffalo Bills win and cover 35-21.

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