New York Giants vs Los Angeles Rams Picks and Prediction for Monday September 21 2026

By: Eddie Kline Published 09/14/2026, 09:08 PM ET

Giants Preview

Beautiful SoFi Stadium will play host to a Monday night NFL showdown between the New York Giants and the Los Angeles Rams. Get ready for all the football action with our NFL Picks. The Giants have endured at least ten losses in eight of the previous nine seasons and have made just two playoff appearances since winning Super Bowl XLVI. Former Baltimore head coach John Harbaugh was hired to bring some much needed stability to the franchise and a playoff season could be in store. On Sunday night, New York limited a potent Dallas offense to 244 total yards to earn a 28-20 home victory.

Second-year QB Jaxson Dart dazzled the New York crowd with 230 passing yards and three touchdowns. Dart added 54 rushing yards on 11 carries. Cam Skattebo contributed 81 rushing yards and a score. Former Baltimore TE Isaiah Likely shined in his New York debut with eight catches for 78 yards and two touchdowns.

Rams Preview

The Los Angeles Rams entered the 2026 season as the betting favorites to hoist the Vince Lombardi trophy and have all the pieces in place to accomplish that goal. The Rams needed to improve a defense that ranked 12th in EPA and did so by trading for single-season sack record holder Myles Garrett. In the season opener, Los Angeles came away from the Melbourne Game with a 27-7 loss against NFC West Division rival San Francisco.

Los Angeles took a brief lead seconds into the second quarter on a Kyren Williams five-yard touchdown run. Puka Nucua secured five of nine targets and finished with a game-high 74 receiving yards. Veteran QB Matthew Stafford threw for just 155 yards and was picked off in a losing effort for the Rams.

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Giants vs Rams Pick

Los Angeles DE Myles Garrett will undergo a knee scope and will not make his team debut until mid-October at the earliest. The Giants ranked near the bottom of the league in total defense a season ago and took advantage of a Dallas squad missing their left tackle. The Rams will be motivated to put the season opening loss behind them. Take Los Angeles to win and cover at home. Final Score Prediction, Los Angeles Rams win 31-17.

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