New York Jets vs Buffalo Bills Picks and Predictions for Sunday, January 4, 2026

By: Jake Allman Published 12/31/2025, 01:34 AM ET

The Jets and Bills close the regular season on Sunday at 4:25 PM ET from Highmark Stadium on CBS. Buffalo is 11-5 and 6-2 at home, while New York is 3-13 and 1-6 on the road. DraftKings has Buffalo at -11.5 on the spread with the Bills -600 on the moneyline, the Jets +440, and the total sitting at 39.5 in typical cold-weather January conditions with a 24° forecast. Crush the gridiron with our unbeatable NFL picks.

Jets Preview

New York has been sliding hard, losing four of the last five and getting blown out in losses to the Patriots (42-10), Jaguars (48-20), Dolphins (34-10), and Saints (29-6). Justin Fields is listed on IR, and Garrett Wilson is also on IR, which explains the thin passing production from the season leaders. Breece Hall has 954 rushing yards on 229 carries but is questionable with a knee injury, and Isaiah Davis is also questionable with a concussion, so the backfield is not a lock either.

Up front, the Jets have taken a lot of hits in the passing game, with the team totals showing 59 sacks allowed across the season passing line. Jamien Sherwood has been busy with 140 tackles, but the Jets have not slowed anyone lately, giving up 42, 29, 48, and 34 points in four of the last five games.

Bills Preview

Buffalo enters 4-1 over the last five despite a tough 13-12 loss to the Eagles last week. Josh Allen has 3,406 passing yards with 25 touchdowns and 10 picks, and the run game is a real strength with James Cook III at 1,532 yards on 287 carries and 12 rushing scores. Khalil Shakir leads the receiving group with 684 yards on 66 catches, giving the Bills a receiver who helps move the chains.

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Buffalo’s defensive production is more about balance than one monster stat line, with Greg Rousseau at 6.5 sacks and safety Cole Bishop posting 83 tackles and three interceptions. Terrel Bernard is questionable with a calf issue, but the bigger picture is Buffalo consistently playing solid, efficient football, which includes wins over Cleveland, New England, Cincinnati, and Pittsburgh in this recent stretch. At home, with the Jets limping in, Buffalo should control field position and tempo.

Bills vs Jets Prediction

Best Bets: Bills -11.5 and Under 39.5. Buffalo’s offense has enough rushing punch to easily move up and down the field, and New York’s injury list, plus recent poor performances, makes the Jets tough to trust to contribute much to the total. Bills 24, Jets 10. The best sportsbooks are the best way to go when you are betting on the Bills. Make sure you know about how the fans are looking on prediction markets for the Jets with the Onyx Odds promo code. Getting the most out of your bets on Jets vs Bills can be done by using the Fanatics Sportsbook promo code.

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