San Francisco 49ers vs Arizona Cardinals Picks and Predictions for Sunday, November 16, 2025
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San Francisco 49ers vs Arizona Cardinals Game Information
The San Francisco 49ers will return to the road this week for a game in Arizona against the Arizona Cardinals at 4:05 PM. San Francisco has six wins and four losses, having dropped three of the last five following a 16-point home loss to Los Angeles a week ago. The Arizona Cardinals will be back on their home field this week, with three wins and six losses overall, after dropping four of the last five, including a 22 on the road loss to Seattle last week. Stay in the news with our NFL Picks.
San Francisco 49ers Preview
Mac Jones leads the San Francisco offense this season with 1832 yards and 10 touchdowns on 168 completions. Brock Purdy has completed 48 passes for 586 yards and four scores, but has played in just two games. Christian McCaffrey leads San Francisco with 596 yards and four scores on 168 carries, to go along with a team-leading 626 yards and four touchdowns on 61 receptions. Kendrick Bourne is second on the roster with 463 yards on 30 grabs this season. Make sure you know about how the fans are looking on social for San Francisco with the Novig promo code.
Arizona Cardinals Preview
Kyler Murray is the offensive leader this season for Arizona with 962 yards and six touchdowns on 110 completions, to go along with the team-leading 173 yards and two scores on 29 carries. Jacoby Brissett has completed 73 passes for 860 yards and six scores this season. Marvin Harrison Jr leads Arizona this season with 492 yards and three touchdowns on 31 receptions. Trey McBride has added 52 catches for 476 yards and 5 touchdowns. Check out all the sportsbook promos to see if you are getting a great deal on your bets on Arizona.
San Francisco 49ers vs Arizona Cardinals Prediction
San Francisco is having a down year, but will do the work on the road this week. Look for the 49ers to control this game on both sides of the ball against a lackluster Arizona team. Take the 49ers to get a needed victory this week as they get it done against a divisional rival in Arizona. Final Score Prediction, San Francisco 49ers win and cover 27-13. Make sure when you place your bet on 49ers vs Cardinals you are using the BetMGM bonus code.
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49ers vs Cardinals Best Picks
- San Francisco -2.5
- Under 48.5
