San Francisco 49ers vs Philadelphia Eagles Picks & Prediction (Wild Card) — Sunday, January 11, 2026

By: Kim Smith Published 01/10/2026, 01:52 AM ET

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The San Francisco 49ers (12-5, 7-2 away) head to Lincoln Financial Field to take on the Philadelphia Eagles (11-6, 5-3 home) in the wild-card round on Sunday, January 11, 2026, with kickoff set for 4:30 PM ET on FOX. The weather in Philadelphia is listed at 42°, which is chilly but not extreme.

San Francisco Purdy Leads The Waye

San Francisco’s offense is built around Brock Purdy (2,167 passing yards, 20 TD, 10 INT) and the engine that is Christian McCaffrey, who leads the team in both rushing (1,202 yards, 10 TD) and receiving (924 yards, 102 catches, 7 TD). Defensively, Clelin Ferrell leads the Niners with 4 sacks, while Dee Winters tops the tackle list at 101 (and is also listed as questionable with an ankle issue). On the injury report, the 49ers have Keion White, Renardo Green, Luke Gifford, and Dee Winters all questionable, while Jacob Cowing is on IR.

Jalen Hurts Looks To Lay Down The Hurt

Philadelphia counters with Jalen Hurts (3,224 passing yards, 25 TD, 6 INT) and a balanced attack featuring Saquon Barkley (1,140 rushing yards, 7 TD). In the passing game, DeVonta Smith leads the team with 1,008 receiving yards. Defensively, Jalyx Hunt paces the Eagles with 6.5 sacks, and Zack Baun leads the way in tackles with 123. Injury-wise, the Eagles list Lane Johnson as questionable (foot), Brett Toth as questionable (concussion), and have Azeez Ojulari on IR, along with Myles Hinton and Willie Lampkin both on IR.

Last 5 Reflection

Looking at recent form, San Francisco’s last five include a 13-3 loss vs Seattle (1/3/26), but also strong wins over Chicago (42-38), Indianapolis (48-27), Tennessee (37-24), and Cleveland (26-8). Philadelphia’s last five show a stumble most recently with a 24-17 loss vs Washington (1/4/26), but they also beat Buffalo (13-12), Washington (29-18), and Las Vegas (31-0), with a 22-19 OT loss at the Chargers mixed in.

Pick & Prediction

I’m backing San Francisco +6. Getting nearly a touchdown with a 12-win team that runs through McCaffrey’s versatility is the side I want, especially with the matchup predictor still showing this as a fairly competitive game. For the total, I lean Under 44.5 with both teams capable of leaning on the run game (McCaffrey and Barkley) and with January football conditions in Philadelphia encouraging longer drives and fewer explosive plays.

Final Score Prediction: Eagles 23, 49ers 20

#	Handicapper	Profit
1	Bruce Marshall	+8,742.00
2	Bryan Power	+3,958.00
3	Sean Higgs	+2,820.00
4	David Hess	+1,870.00
5	Steve Seagrave	+1,832.00

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