San Francisco 49ers vs Seattle Seahawks Picks and Prediction for Saturday January 17 2026

By: Eddie Kline Updated 01/21/2026, 02:45 PM ET

49ers Preview

Luman Field will be rocking on Saturday night, when the San Francisco 49ers battle the Seattle Seahawks in the NFL Divisional Round. Get ready for all the football action with our NFL Picks. The sixth-seeded 49ers (12-5) were decimated by injuries this season, but head coach Kyle Shanahan has his team in position to win their first Super Bowl since 1994. On Sunday, San Francisco outscored Philadelphia by ten points in the fourth quarter to escape with a 23-19 road victory.

San Francisco took the lead for good on a Brock Purdy four-yard touchdown pass to Christian McCaffrey with less than three minutes remaining. DeMarcus Robinson caught six passes for a game-high 111 yards and a score. The 49ers outgained the Eagles by a 361-307 margin and committed just one accepted penalty.

Seahawks Preview

The Seattle Seahawks are riding a seven-game winning streak and locked up their first NFC West Division title since 2020. The top-seeded Seahawks (14-3) rank sixth in the league in total defense and are allowing 17.2 points per contest. In the regular season finale, Seattle limited San Francisco to 173 total yards during a 13-3 road triumph.

Zach Charbonnet started the scoring for Seattle with a 27-yard touchdown run. Kenneth Walker III contributed a game-high 97 rushing yards on 16 carries. All-Pro WR Jaxon Smith-Njigba added 84 receiving yards for the Seahawks.

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49ers vs Seahawks Pick

San Francisco TE suffered a torn Achilles during Sunday’s victory and will miss the remainder of the postseason. Having All-Pro OT Trent Williams return from injury was a major factor for the 49ers on Sunday. If he can stay healthy, Brock Purdy can do enough to keep this thing close. Take the points. Final Score Prediction, Seattle Seahawks win 24-21.

How To Bet This Matchup

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