Seattle Seahawks vs Arizona Cardinals Picks and Prediction for Thursday September 25 2025

By: Eddie Kline Updated 09/26/2025, 01:00 PM ET

Seahawks Preview

The week four NFL schedule will kick off on Thursday night with a matchup between the Seattle Seahawks and the Arizona Cardinals from State Farm Stadium. Experience the thrill of confident decision-making with our proven methods for selecting top free NFL picks. The Seahawks (2-1) have scored 75 points in their last two games and rank second in the league in scoring defense (15.7 ppg). On Sunday, Tory Horton’s 95-yard punt return touchdown propelled Seattle to a 44-13 home victory versus New Orleans.

Jaxson Smith-Njigba caught a 12-yard touchdown and Kenneth Walker III added a three-yard score as Seattle raced out to a 21-0 first quarter advantage. Sam Darnold connected with Horton on a 14-yard touchdown for the Seahawks, who averaged 5.9 yards per play.

Cardinals Preview

The Arizona Cardinals made a four-win improvement last season and have the talent to contend for a playoff spot this year. The Cardinals (2-1) rank fourth in the league in rushing defense (76.3 ypg) and are allowing 17 points per contest. On Sunday, Arizona surrendered a 35-yard field goal as time expired during a 16-15 road loss against San Francisco.

Arizona managed just two short Chad Ryland field goals through the first three quarters. Kyler Murray found TE Trey McBride for a one-yard touchdown pass to even the score at 13 with eight plus minutes remaining. Marvin Harrison Jr. caught three passes for 44 yards in a losing effort for the Cardinals.

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Seahawks vs Cardinals Pick

Arizona RB James Conner suffered a right ankle injury during Sunday’s loss and will miss the remainder of the season. These two teams have been getting the job done on the defensive side of the ball, so the under is worth a look. The stronger play is on the Seahawks to win on the road. Final Score Prediction, Seattle Seahawks win 24-19.

Betting on the NFL?

Be sure to look our our list of the best NFL online sportsbooks
Grow your bankroll by claiming one of our favorite NFL sportsbook promo codes

Min. Deposit $5

Cashable No

Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.

Requirement New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)

Cashable No

Gambling Problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Call 1-888-789-7777 or visit ccpg.org/chat (CT). Hope is here. GamblingHelplineMA.org or call (800) 327-5050 for 24/7 support (MA). Visit www.mdgamblinghelp.org (MD). Call 1-877-HOPENY or text HOPENY (467369) (NY). 21+ (18+ DC, IA, KY, WV) only. New users only or text HOPENY (467369) (NY). Casino, First online real money wager only. $5 first deposit required. Min $5 wager required for 5 consecutive days. Bonus issued as non-withdrawable Bet Reset tokens. Refund from token issued as nonwithdrawable bonus bet that expire 7 days after receipt. Max refund $200 per day. Restrictions apply, including token expiration. See full terms at fanduel.com/sportsbook. Call 1-877-770-7867 (LA).

Min. Deposit $5

Odds Requirements -500

Cashable No

GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/NH/PR/WY). Void in CAN. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $200 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 7/19/26 at 11:59 PM ET. Sponsored by DK.