Seattle Seahawks vs Arizona Cardinals Picks, Prediction, Odds, and Line Movement for Sunday September 20 2026
What a difference from a week ago, when the Seahawks were on top of the world as defending champs and the Cardinals were regarded as a serious candidate to earn the top pick in next April's NFL draft, a swing in perception that shapes these Cardinals vs Seahawks picks. Seattle survived, barely, its opener in a Super Bowl rematch against the Patriots, while Arizona looked like a legit NFL team behind Jacoby Brissett. For more matchups this week, check out our full slate of NFL picks before placing a wager.
TLDR: Quick Picks and Prediction
- Spread Pick: Arizona Cardinals +4.5
- Total Pick: Under 41.5
- Projected Final Score: Seahawks 20, Cardinals 17
Odds and Line Movement
Current Odds
| Market | Line | Public Betting ($, #) |
|---|---|---|
| Spread (Seattle / Arizona) | SEA -4.5 (-102) / ARI +4.5 (-120) | SEA 57%, SEA 70% |
| Total (Over / Under) | Over 41.5 (-102) / Under 41.5 (-120) | UN 99%, OV 52% |
Line Movement - Spread
| Date | Seattle | Arizona | Public Betting ($, #) |
|---|---|---|---|
| 09/16 | -4.5 (-102) | +4.5 (-120) | SEA 57%, SEA 70% |
| 09/16 | -4.5 (-104) | +4.5 (-118) | SEA 57%, SEA 70% |
| 09/15 | -4.5 (-105) | +4.5 (-115) | ARI 54%, ARI 71% |
| 09/15 | -4.5 (-108) | +4.5 (-112) | SEA 71%, SEA 75% |
| 09/13 | -4.5 (-115) | +4.5 (-105) | ARI 92%, ARI 75% |
| 09/13 | -5 (-105) | +5 (-115) | ARI 92%, ARI 73% |
| 09/13 | -5.5 (-110) | +5.5 (-110) | ARI 94%, ARI 75% |
| 09/13 | -6.5 (-105) | +6.5 (-115) | ARI 95%, SEA 50% |
| 09/08 | -9.5 (-105) | +9.5 (-115) | SEA 100%, SEA 100% |
Line Movement - Total
| Date | Over | Under | Public Betting ($, #) |
|---|---|---|---|
| 09/16 | 41.5 (-102) | 41.5 (-120) | UN 99%, OV 52% |
| 09/14 | 41.5 (-105) | 41.5 (-115) | UN 100%, UN 71% |
| 09/14 | 40.5 (-110) | 40.5 (-110) | UN 100%, UN 71% |
| 09/14 | 41.5 (-105) | 41.5 (-115) | UN 100%, UN 100% |
| 09/13 | 41.5 (-110) | 41.5 (-110) | UN 100%, UN 100% |
| 09/13 | 41.5 (-115) | 41.5 (-105) | UN 100%, UN 100% |
| 09/13 | 43.5 (-104) | 43.5 (-118) | N/A |
| 09/08 | 44.5 (-102) | 44.5 (-120) | N/A |
Seahawks vs Cardinals Key Matchups and Game Preview
Cardinals Stun Chargers Behind Brissett
For one game at least, the Big Red looked like a legit NFL team for new head coach Mike LaFleur, who had the offense moving smartly for the entire 60 minutes behind Jacoby Brissett, who went 27-of-37 for 277 yards passing at SoFi against the Chargers. That kind of efficient, sustained performance was a welcome sight for a team that entered the week facing modest expectations.
Arizona's Defense Flusters Herbert
The Cardinals' defense completely flustered Justin Herbert in a surprisingly handy 26-14 win as a nine-point road underdog. Week 1 has been known to deliver these sorts of unexpected surprises in the recent past, so there is reason to proceed with some caution, but the performance still stands out as a real signal for where this Arizona team is headed.
SEA Survives Behind Backup QB
Seattle did survive, barely, its opener in the Super Bowl rematch against the Patriots, but quarterback Sam Darnold was sidelined early with a hip injury and had to rely on backup Drew Lock to get across the tape. It was not a clean effort by the champs, who hurt themselves with numerous mental mistakes, including three false-start penalties.
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Seahawks Rocked by Darnold Injury
Seattle needed Drake Maye to toss three ill-advised interceptions, including a regrettable gaffe in the final minute, to escape with the win. It might not be asking much of Brissett to avoid those sorts of mistakes, and with Darnold's status uncertain, Lock is likely in again for Seattle in this matchup.
Cardinals Riding Rookie Boost
With Notre Dame rookie running back Jeremiyah Love on the verge of making some very exciting contributions in the desert, the Cardinals are not looking like the pushovers they were pre-LaFleur last year, at least not yet. Lock and Jaxon Smith-Njigba are capable of getting Seattle across the line, but laying points, even at a reduced price, looks like a bit of a risk given how the Cardinals have performed.
Betting Trends: ARI vs SEA
- Arizona beat the Chargers 26-14 as a nine-point road underdog in Week 1.
- Jacoby Brissett completed 27 of 37 passes for 277 yards in that win.
- Seattle survived a Super Bowl rematch against the Patriots despite three false-start penalties and Drake Maye's three interceptions.
- Sam Darnold was sidelined early with a hip injury, forcing backup Drew Lock into extended action.
- The spread has moved from Seattle -9.5 on September 8 down to Seattle -4.5 currently.
- The total has fallen from 44.5 down to 41.5 over the course of the week, with heavy public backing on the Under.
Key Injuries and Things To Know: ARI and SEA
- Sam Darnold suffered a hip injury in Week 1 and Drew Lock is likely to start again for Seattle.
- Rookie running back Jeremiyah Love is emerging as a key contributor for Arizona's offense.
- Jacoby Brissett threw for 277 yards on 27-of-37 passing in Arizona's Week 1 win.
- Drake Maye threw three interceptions in New England's Week 1 loss to Seattle.
- Seattle committed three false-start penalties in a game that was closer than expected.
Seahawks vs Cardinals Side and Over/Under Picks
- Spread: Arizona Cardinals +4.5
- Total: Under 41.5
Laying points with Seattle, even at a reduced price, looks like a bit of a risk given how sloppy the champs looked in Week 1 and the uncertainty surrounding Sam Darnold. Arizona's defense flustered Justin Herbert, and with Jeremiyah Love emerging as a weapon, the Cardinals have the pieces to keep this one within a possession. On the total, the number has already fallen from 44.5 to 41.5, with heavy public backing on the Under supporting a lower-scoring outcome.
Final Score Prediction
- Seattle Seahawks: 20
- Arizona Cardinals: 17
Expect a tight, low-scoring affair with Seattle holding on behind Drew Lock while Arizona's defense and improving offense keep the Cardinals within striking distance throughout.
How to Wager On Cardinals vs Seahawks
Bettors looking to shop for the best number on Cardinals vs Seahawks have several tools available before placing a wager. Comparing the spread and total across multiple sportsbooks can help secure better value than settling for a single closing line, especially with a number that has moved several points throughout the week. For those who want an extra layer of analysis before betting this NFC West matchup, our AI picks breakdown is a useful starting point. Bettors can also dig deeper with our Dimers review and Oddible review to see how different models project this matchup before locking in a side, total, or player prop.
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