Tennessee Titans vs Arizona Cardinals Picks and Predictions for Sunday, October 5th, 2025
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Tennessee Titans vs Arizona Cardinals Game Information
The Tennessee Titans will be on the road again this week, with a game at State Farm Stadium in Arizona against the Arizona Cardinals on Sunday at 4:05 PM. Tennessee was the worst team in the NFL, winless through four games played, following a blowout loss a week ago. The Arizona Cardinals stay on their home field this week with two wins and two losses on the year, riding a 2-game losing streak after a three-point loss to Seattle last time out. Stay ahead of the game by using our free NFL picks that harness emotional insights to drive results.
Tennessee Titans Preview
The Tennessee Titans have been one of the worst teams in the league on both sides of the ball through the first four games, coming into this matchup with a winless record. Through four games this season, Tennessee's offense is averaging just 12.75 points per game overall. Defensively, the Titans are allowing 30 points per game. Number one pick Cam Ward leads the Tennessee offense this season with 614 yards and two scores on 64 completions. Tony Pollard is the top ball carrier with 68 carries for 261 yards and one score. Elic Ayomanor leads the team with 12 catches for 151 yards and two scores this season.
Arizona Cardinals Preview
Arizona has been up and down to start the year, averaging 20.5 points per game overall. Defensively, Arizona is allowing 18.5 points per game overall but has allowed 19.5 points per game during its two-game losing streak. Former number one overall pick Kyler Murray is leading the Arizona offense this season with 742 yards and six touchdowns on 87 completions. Trey Benson leads the Arizona offense out of the backfield with 160 yards on 29 carries this season. Trey McBride has been the top target in the Arizona offense with 234 yards and one touchdown on 24 grabs. Marvin Harrison Jr. has added 16 catches for 208 yards and two touchdowns this season.
Tennessee Titans vs Arizona Cardinals Game Prediction
The Cardinals are the better team in this matchup and need the win to get their season back on track. Tennessee is one of the worst teams in football, and they will continue to struggle this week. Look for the Cardinals to control this game start to finish, leading to their third win of the season following the win and cover. Final Score Prediction, Arizona Cardinals win and cover 27-10.
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Cardinals vs 49ers Best Picks
- Arizona Cardinals -8.5
- Under 40.5
